Electrochemical late-stage functionalization
Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …
diversification of novel molecular entities with improved physicochemical or biological …
Applications of halogen-atom transfer (XAT) for the generation of carbon radicals in synthetic photochemistry and photocatalysis
The halogen-atom transfer (XAT) is one of the most important and applied processes for the
generation of carbon radicals in synthetic chemistry. In this review, we summarize and …
generation of carbon radicals in synthetic chemistry. In this review, we summarize and …
Current contributions of organofluorine compounds to the agrochemical industry
Y Ogawa, E Tokunaga, O Kobayashi, K Hirai… - Iscience, 2020 - cell.com
Summary Currently, more than 1,200 agrochemicals are listed and many of these are
regularly used by farmers to generate the food supply to support the expanding global …
regularly used by farmers to generate the food supply to support the expanding global …
Chemical aspects of human and environmental overload with fluorine
Over the last 100–120 years, due to the ever-increasing importance of fluorine-containing
compounds in modern technology and daily life, the explosive development of the …
compounds in modern technology and daily life, the explosive development of the …
Fluorination enhances NIR‐II emission and photothermal conversion efficiency of phototheranostic agents for imaging‐guided cancer therapy
C Li, G Jiang, J Yu, W Ji, L Liu, P Zhang… - Advanced …, 2023 - Wiley Online Library
Phototheranostics with second near‐infrared (NIR‐II) imaging and photothermal effect have
become a burgeoning biotechnology for tumor diagnosis and precise treatment. As …
become a burgeoning biotechnology for tumor diagnosis and precise treatment. As …
Contemporary synthetic strategies in organofluorine chemistry
R Britton, V Gouverneur, JH Lin, M Meanwell… - Nature Reviews …, 2021 - nature.com
Fluorinated molecules have a wide range of applications and are used as medicines,
agrochemicals and refrigerants and in smartphone liquid crystal displays, photovoltaic solar …
agrochemicals and refrigerants and in smartphone liquid crystal displays, photovoltaic solar …
Fluorine-containing drugs approved by the FDA in 2021
J He, Z Li, G Dhawan, W Zhang, AE Sorochinsky… - Chinese Chemical …, 2023 - Elsevier
Nine new fluorine-containing drugs have been approved by the US Food and Drug
Administration (FDA) in 2021, which are presented in this review article. These small …
Administration (FDA) in 2021, which are presented in this review article. These small …
Metabolic and pharmaceutical aspects of fluorinated compounds
BM Johnson, YZ Shu, X Zhuo… - Journal of medicinal …, 2020 - ACS Publications
The applications of fluorine in drug design continue to expand, facilitated by an improved
understanding of its effects on physicochemical properties and the development of synthetic …
understanding of its effects on physicochemical properties and the development of synthetic …
Fluorine and fluorinated motifs in the design and application of bioisosteres for drug design
NA Meanwell - Journal of medicinal chemistry, 2018 - ACS Publications
The electronic properties and relatively small size of fluorine endow it with considerable
versatility as a bioisostere and it has found application as a substitute for lone pairs of …
versatility as a bioisostere and it has found application as a substitute for lone pairs of …
Electrochemical strategies for C–H functionalization and C–N bond formation
MD Kärkäs - Chemical Society Reviews, 2018 - pubs.rsc.org
Conventional methods for carrying out carbon–hydrogen functionalization and carbon–
nitrogen bond formation are typically conducted at elevated temperatures, and rely on …
nitrogen bond formation are typically conducted at elevated temperatures, and rely on …