[HTML][HTML] Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety

CJ Borgert, C Fuentes, LD Burgoon - Archives of Toxicology, 2021 - Springer
Regulatory toxicology seeks to ensure that exposures to chemicals encountered in the
environment, in the workplace, or in products pose no significant hazards and produce no …

[PDF][PDF] Manganese in drinking-water: background document for development of WHO guidelines for drinking-water quality

World Health Organization - 2004 - apps.who.int
One of the primary goals of WHO and its member states is that “all people, whatever their
stage of development and their social and economic conditions, have the right to have …

Confounding parameters in preclinical assessment of blood–brain barrier permeation: an overview with emphasis on species differences and effect of disease states

AK Deo, FP Theil, JM Nicolas - Molecular pharmaceutics, 2013 - ACS Publications
Drug delivery across the brain–blood interfaces is a complex process involving
physicochemical drug properties, transporters, enzymes, and barrier dysfunction in diseased …

Toxicity assessment of manganese oxide micro and nanoparticles in Wistar rats after 28 days of repeated oral exposure

SP Singh, M Kumari, SI Kumari… - Journal of Applied …, 2013 - Wiley Online Library
In the near future, nanotechnology is envisaged for large‐scale use. Hence health and
safety issues of nanoparticles (NPs) should be promptly addressed. Twenty‐eight‐day oral …

Derivation of an occupational exposure level for manganese in welding fumes

LA Bailey, LE Kerper, JE Goodman - Neurotoxicology, 2018 - Elsevier
Exposure to high levels of manganese (Mn) in occupational settings is known to lead to
adverse neurological effects. Since Mn is an essential nutrient, there are mechanisms that …

The application of PBPK models in estimating human brain tissue manganese concentrations

SP Ramoju, DR Mattison, B Milton, D McGough… - Neurotoxicology, 2017 - Elsevier
Mn is an essential element that causes neurotoxicity in humans when inhaled at high
concentrations. This metal has well-recognized route-dependent differences in absorption …

Probabilistic risk assessment of residential exposure to electric arc furnace steel slag using Bayesian model of relative bioavailability and PBPK modeling of …

L Mittal, CS Perry, AD Blanchette, DM Proctor - Risk Analysis, 2024 - Wiley Online Library
Electric arc furnace (EAF) slag is a coproduct of steel production used primarily for
construction purposes. Some applications of EAF slag result in residential exposures by …

Effects of manganese exposure on visuoperception and visual memory in schoolchildren

D Hernández-Bonilla, C Escamilla-Núñez, D Mergler… - Neurotoxicology, 2016 - Elsevier
Abstract Background Manganese (Mn) is an essential metal involved in multiple
physiological functions. Environmental exposure to airborne Mn is associated with …

[HTML][HTML] Use of physiologically based pharmacokinetic modeling to support development of an acute (24-hour) health-based inhalation guideline for manganese

CS Perry, AD Blanchette, SN Vivanco… - Regulatory Toxicology …, 2023 - Elsevier
The toxicokinetics of manganese (Mn) are controlled through homeostasis because Mn is an
essential element. However, at elevated doses, Mn is also neurotoxic and has been …

Genotoxicity of nano-and micron-sized manganese oxide in rats after acute oral treatment

SP Singh, M Kumari, SI Kumari, MF Rahman… - … /Genetic Toxicology and …, 2013 - Elsevier
The use of nanotechnology has led to rapid growth in various areas. Manganese oxide
(MnO2) nanomaterials (NMs) are typically used for biomedical applications. However …