LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission,
are widespread phenomena expressed at possibly every excitatory synapse in the …

The ubiquitin proteasome system (UPS) is the major protein quality control system in
eukaryotic cells. Many neurodegenerative diseases are characterized by aggregates and …

Genetic deletion of fragile X mental retardation protein (FMRP) has been shown to enhance
mGluR-dependent long-term depression (LTD). Herein, we demonstrate that mGluR-LTD …

The anaphase-promoting complex (APC) is a multisubunit E3 ubiquitin ligase that targets
key cell cycle regulatory proteins for degradation. Blockade of APC activity causes mitotic …

The ataxia (axJ) mutation is a spontaneous recessive mutation that results in reduced
expression of ubiquitin‐specific protease 14, Usp14. Mice homozygous for the axJ mutation …

Chronic alcohol exposure induces lasting behavioral changes, tolerance, and dependence.
This results, at least partially, from neural adaptations at a cellular level. Previous genome …

Because activation of ERK1/2 MAP kinase (MAPK) is critical for hippocampus-dependent
memory, there is considerable interest in mechanisms for regulation of MAPK during …

The ubiquitin proteasome system, generally known for its function in protein degradation,
also appears to play an important role in regulating membrane trafficking. A role for the …

The ubiquitin proteasome pathway has been implicated in the pathogenesis of many
neurodegenerative diseases, and alterations in two different deubiquitinating enzymes, Uch …

Ubiquitin-mediated protein degradation has been proposed to play an important role in
regulating synaptic transmission. Here we show that LIN-23, the substrate binding subunit of …