Cardiovascular disease in women remains under-diagnosed and under-treated. Recent
studies suggest that this is caused, at least in part, by the lack of sex-specific diagnostic …

The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

Single cardiomyocytes contain myofibrils that harbor the sarcomere-based contractile
machinery of the myocardium. Cardiomyocytes differentiated from human pluripotent stem …

Alya is a multi-physics simulation code developed at Barcelona Supercomputing Center
(BSC). From its inception Alya code is designed using advanced High Performance …

Patient-specific computer models have been developed representing a variety of aspects of
the cardiovascular system spanning the disciplines of electrophysiology, electromechanics …

Integration of data across spatial, temporal, and functional scales is a primary focus of
biomedical engineering efforts. The advent of powerful computing platforms, coupled with …

Human-based computational modelling and simulation are powerful tools to accelerate the
mechanistic understanding of cardiac patho-physiology, and to develop and evaluate …

The combination of computational models and biophysical simulations can help to interpret
an array of experimental data and contribute to the understanding, diagnosis and treatment …

The heart pumps blood to maintain circulation and ensure the delivery of oxygenated blood
to all the organs of the body. Mechanics play a critical role in governing and regulating heart …

Mechano‐electric regulations (MER) play an important role in the maintenance of cardiac
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …