[HTML][HTML] Exercise is medicine for nonalcoholic fatty liver disease: exploration of putative mechanisms

JW Heinle, K DiJoseph, A Sabag, S Oh, SR Kimball… - Nutrients, 2023 - mdpi.com
Exercise remains a key component of nonalcoholic fatty liver disease (NAFLD) treatment.
The mechanisms that underpin improvements in NAFLD remain the focus of much …

[HTML][HTML] Autophagy: A Cellular Guardian against Hepatic Lipotoxicity

RA Sinha - Genes, 2023 - mdpi.com
Lipotoxicity is a phenomenon of lipid-induced cellular injury in nonadipose tissue. Excess of
free saturated fatty acids (SFAs) contributes to hepatic injury in nonalcoholic fatty liver …

Thyroid function, adipokines and mitokines in metabolic dysfunction‐associated steatohepatitis: A multi‐centre biopsy‐based observational study

M Kouvari, L Valenzuela‐Vallejo… - Liver …, 2024 - Wiley Online Library
Abstract Background and Aims Thyroid axis is currently under investigation as a therapeutic
target in metabolic dysfunction‐associated steatotic liver disease (MASLD). Thyroid function …

Emerging drug therapies for metabolic dysfunction-associated steatotic liver disease: a glimpse into the horizon

J Arnold, F Idalsoaga, LA Díaz, D Cabrera… - Current Hepatology …, 2024 - Springer
Abstract Purpose of Review Metabolic dysfunction–associated steatotic liver disease
(MASLD) and its aggressive form, metabolic dysfunction-associated steatohepatitis (MASH) …

Hormone action and liver disease, a complex interplay

L Marino, A Kim, B Ni, FS Celi - Hepatology, 2023 - journals.lww.com
Thyroid hormone action is involved in virtually all physiological processes. It is well known
that the liver and thyroid are intimately linked, with thyroid hormone playing important roles …

Inflammatory liver diseases and susceptibility to sepsis

H Lu - Clinical Science, 2024 - portlandpress.com
Patients with inflammatory liver diseases, particularly alcohol-associated liver disease and
metabolic dysfunction-associated fatty liver disease (MAFLD), have higher incidence of …

siRNA-mediated gene silencing for non-alcoholic fatty liver disease: A comprehensive review of molecular targets

A Mahmoudi, M Rostami, MM Hajihasani… - European Polymer …, 2024 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a burgeoning global public health distress, with
an estimated 25% of the world population affected. Despite the increasing prevalence and …

TRβ Agonism Induces Tumor Suppression and Enhances Drug Efficacy in Anaplastic Thyroid Cancer in Female Mice

NE Gillis, LM Cozzens, ER Wilson, NM Smith… - …, 2023 - academic.oup.com
Thyroid hormone receptor beta (TRβ) is a recognized tumor suppressor in numerous solid
cancers. The molecular signaling of TRβ has been elucidated in several cancer types …

[HTML][HTML] Targeting nuclear receptors for NASH/MASH: From bench to bedside

RA Sinha - Liver research, 2024 - Elsevier
The onset of metabolic dysfunction-associated steatohepatitis (MASH) or non-alcoholic
steatohepatitis (NASH) represents a tipping point leading to liver injury and subsequent …

A thyroid hormone receptor beta specific agonist suppresses anaplastic thyroid cancer cell phenotype and increases efficacy of therapeutic agents

NE Gillis, CD Davidson, LM Cozzens, E Wilson, EL Bolf… - bioRxiv, 2021 - biorxiv.org
Background Anaplastic thyroid cancer (ATC) is one of the most lethal endocrine cancers,
with an average survival time of six months after diagnosis. These aggressive tumors have …