Therapeutic drug monitoring (TDM) opens the door to personalized medicine, yet it is
infrequently applied to β‐lactam antibiotics, one of the most commonly prescribed drug …

Optimizing the prescription of antimicrobials is required to improve clinical outcome from
infections and to reduce the development of antimicrobial resistance. One such method to …

Introduction Altered pharmacokinetics (PK) in critically ill patients can result in insufficient
serum β-lactam concentrations when standard dosages are administered. Previous studies …

Abstract Background and purpose The Japanese Clinical Practice Guidelines for
Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of …

Extracorporeal membrane oxygenation (ECMO) is a form of prolonged cardiopulmonary
bypass used to temporarily sustain cardiac and/or respiratory function in critically ill patients …

The extreme pharmacokinetic behaviour of drugs sometimes observed in critically ill patients
poses a significant threat to the achievement of optimal antibiotic treatment outcomes. Scant …

Introduction Vital drugs may be degraded or sequestered in extracorporeal membrane
oxygenation (ECMO) circuits, with lipophilic drugs considered to be particularly vulnerable …

The prescription of pharmaceuticals in the critically ill is complicated by a paucity of
knowledge concerning the pharmacokinetic implications of the underlying disease state …

Purpose An understanding of the pharmacokinetic (PK) and pharmacodynamic (PD)
principles that determine response to antimicrobial therapy can provide the clinician with …

Introduction Extracorporeal membrane oxygenation (ECMO) is a supportive therapy, with its
success dependent on effective drug therapy that reverses the pathology and/or normalizes …