Critically ill patients can display markedly abnormal physiological parameters compared
with those in ward-based or ambulatory settings. As a function of both the underlying …

The aim of this study was to evaluate the effect of augmented renal clearance (ARC) on
vancomycin serum concentrations in critically ill patients. This prospective, single-centre …

Introduction Improved methods to optimize drug dosing in the critically ill are urgently
needed. Traditional prescribing culture involves recognition of factors that mandate dose …

A simple and economical high performance liquid chromatography method was developed
and validated for routine analysis of 12 Penicillin, Cephalosporin and Carbapenem …

Introduction It has been proposed that doses of amikacin of> 15 mg/kg should be used in
conditions associated with an increased volume of distribution (V d), such as severe sepsis …

Initial adequate anti-infective therapy is associated with significantly improved clinical
outcomes for patients with severe infections. However, in critically ill patients, several …

The objective of the present retrospective observational study carried out in patients
receiving a standard dosage of linezolid and undergoing routine therapeutic drug …

The objectives of this study were (i) to compare the plasma concentration–time profiles for
first-dose and steady-state piperacillin administered by intermittent or continuous dosing to …

For the optimization of dosing regimens of anti-infective agents, it is imperative to have a
good understanding of pharmacokinetics (PK) and pharmacodynamics (PD). Whenever …

Obesity causes a number of changes, including an increase in volume of distribution and
changes in hepatic metabolism and renal excretion. Several antibiotics have sufficient data …