Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Leptin is an adipocyte-secreted hormone that has been proposed to regulate energy
homeostasis as well as metabolic, reproductive, neuroendocrine, and immune functions. In …

Is depression simply the result of chemical imbalances, or Schizophrenia a wholly biological
disorder? What role do the broader circumstances of an individual's social, cultural and …

Liver cirrhosis is frequently accompanied by disease-related malnutrition (DRM) and
sarcopenia, defined as loss of skeletal muscle mass and function. DRM and sarcopenia …

Maintenance of human energy homeostasis is regulated by a complex network. Peptides
secreted from the gastrointestinal tract (GI) are signaling to the brain and other organs …

The 21st century is characterized by an increasing incidence and prevalence of obesity and
the burden of its associated comorbidities, especially cardiometabolic diseases, which are …

Recent proof-of-concept studies involving leptin administration to humans underline the
critical role of leptin not only in regulating energy homeostasis, but also in maintaining …

Functional hypothalamic amenorrhea (FHA) is defined as a non-organic and reversible
disorder in which the impairment of gonadotropin-releasing hormone (GnRH) pulsatile …

Coronary heart disease (CHD) is the leading cause of mortality in Western societies,
affecting about one third of the population before their seventieth year. Over the past …

Skeletal growth is tightly coupled to energy balance via complex and incompletely
understood mechanisms. Leptin-deficient ob/ob mice are obese and develop multiple …