Itraconazole is an orally active antifungal agent that has complex and highly variable
absorption kinetics that is highly affected by food. This study aimed to develop a population …

Background Therapeutic drug monitoring and Model-informed precision dosing allow dose
individualization to increase drug effectivity and reduce toxicity. Objectives To evaluate the …

Serum cystatin C has been proposed as a kidney biomarker to inform drug dosing. We
conducted a systematic review to synthesize available data for the association between …

Building a covariate model is a crucial task in population pharmacokinetics and
pharmacodynamics in order to understand the determinants of the interindividual variability …

The current healthcare system is widely based on the concept of “one size fit for all”, which
emphasizes treating a disease by prescribing the same drug to all patients with equivalent …

Background Cough in asthmatic patients is a common and troublesome symptom. It is
generally assumed coughing occurs as a consequence of bronchial hyperresponsiveness …

Tacrolimus, a calcineurin inhibitor, is a common immunosuppressant prescribed after organ
transplantation and has notable inter‐and intrapatient pharmacokinetic variability. The …

Mathematical modeling in the field of glucose metabolism has a longstanding tradition. The
use of models is motivated by several reasons. Models have been used for calculating …

Interactive applications, developed using Shiny for the R programming language, have the
potential to revolutionize the sharing and communication of pharmacometric model …

Abstract Background and Objective Escitalopram and sertraline are commonly prescribed
for anxiety and depressive disorders in children and adolescents. The pharmacokinetics …