A common feature of human and veterinary pharmacokinetics is the importance of
identifying and quantifying the key determinants of between‐patient variability in drug …

Anticancer agents often have a narrow therapeutic index (TI), requiring precise dosing to
ensure sufficient exposure for clinical activity while minimizing toxicity. These agents …

This article seeks to address the prevailing issue of how to measure specific process
components of psychobiological stress responses. Particularly the change of cortisol …

The model-informed drug discovery and development paradigm is now well established
among the pharmaceutical industry and regulatory agencies. This success has been mainly …

Physiologically-based pharmacokinetic (PBPK) modeling has emerged as a useful tool to
study pharmacokinetics (PK) in special populations, such as pregnant women, fetuses, and …

Rationale: There is accumulating evidence that higher-than-standard doses of isoniazid are
effective against low-to-intermediate–level isoniazid-resistant strains of Mycobacterium …

Oxycodone is a semisynthetic opioid analgesic that is increasingly used for the treatment of
acute, cancer, and chronic non-malignant pain. Oxycodone was synthesized in 1917 but its …

Background Inhaled capsaicin elicits cough reproducibly in human subjects and is widely
used in the study of cough and antitussive therapies. However, the traditional end points C2 …

Approximately 10% of colorectal cancers harbor BRAF V600E mutations, which
constitutively activate the MAPK signaling pathway. We sought to determine whether ERK …

This collection of contributions from the European Network on Understanding
Gastrointestinal Absorption-related Processes (UNGAP) community assembly aims to …