Decoding the role of miRNAs in multiple myeloma pathogenesis: a focus on signaling pathways

AM Yehia, EGE Elsakka, AI Abulsoud… - … -Research and Practice, 2023 - Elsevier
Multiple myeloma (MM) is a cancer of plasma cells that has been extensively studied in
recent years, with researchers increasingly focusing on the role of microRNAs (miRNAs) in …

CAR-T-Cell therapy in multiple myeloma: B-cell maturation antigen (BCMA) and beyond

AK Mishra, A Gupta, G Dagar, D Das, A Chakraborty… - Vaccines, 2023 - mdpi.com
Significant progress has been achieved in the realm of therapeutic interventions for multiple
myeloma (MM), leading to transformative shifts in its clinical management. While …

Encapsulation of nano‐bortezomib in apoptotic stem cell‐derived vesicles for the treatment of multiple myeloma

Z Cao, P Li, Y Li, M Zhang, M Hao, W Li, X Mao, L Mo… - Small, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are lipid bilayer nanovesicles released from living or apoptotic
cells that can transport DNA, RNA, protein, and lipid cargo. EVs play critical roles in cell–cell …

Aberrant metabolic processes promote the immunosuppressive microenvironment in multiple myeloma

J Lv, H Sun, L Gong, X Wei, Y He, Z Yu, L Liu… - Frontiers in …, 2022 - frontiersin.org
Introduction Multiple myeloma (MM) is still an incurable plasma cell malignancy. The efficacy
of immunotherapy on MM remains unsatisfactory, and the underlying molecular mechanisms …

Obesity and myeloma: Clinical and mechanistic contributions to disease progression

C Marques-Mourlet, R Di Iorio, H Fairfield… - Frontiers in …, 2023 - frontiersin.org
Obesity and obesogenic behaviors are positively associated with both monoclonal
gammopathy of unknown significance (MGUS) and multiple myeloma (MM). As the only …

Single‐cell transcriptome profiling reveals the key role of ZNF683 in natural killer cell exhaustion in multiple myeloma

X Li, M Chen, Y Wan, L Zhong, X Han… - Clinical and …, 2022 - Wiley Online Library
Backgrounds Decreased cytotoxicity of natural killer (NK) cells has been shown in multiple
myeloma (MM). However, the underlying molecular mechanisms remain unclear. Here, by …

New biological therapies for multiple myeloma

AL Garfall - Annual Review of Medicine, 2024 - annualreviews.org
Multiple myeloma is a cancer of bone marrow plasma cells that represents approximately
10% of hematologic malignancies. Though it is typically incurable, a remarkable suite of new …

Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma

Z Yin, Y Lv, L Deng, G Li, R Ou, L Chen, Y Zhu… - Free Radical Biology …, 2023 - Elsevier
Since multiple myeloma (MM) remains a cureless malignancy of plasma cells to date, it
becomes imperative to develop novel drugs and therapeutic targets for MM. We screened a …

Liquid biopsy in hematological malignancies: current and future applications

D Talotta, M Almasri, C Cosentino, G Gaidano… - Frontiers in …, 2023 - frontiersin.org
The assessment of the cancer mutational profile is crucial for patient management,
stratification, and therapeutic decisions. At present, in hematological malignancies with a …

Past, present, and a glance into the future of multiple myeloma treatment

WO Elbezanti, KB Challagundla, SC Jonnalagadda… - Pharmaceuticals, 2023 - mdpi.com
Multiple myeloma (MM) is a challenging hematological cancer which typically grows in bone
marrow. MM accounts for 10% of hematological malignancies and 1.8% of cancers. The …