The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal
role in tissue homeostasis and repair. While the ECM was long thought to mostly have …

Simple Summary Cell migration is an essential process from embryogenesis to cell death.
This is tightly regulated by numerous proteins that help in proper functioning of the cell. In …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Actin plays roles in many important cellular processes, including cell motility, organelle
movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the …

Cell migration controls developmental processes (gastrulation and tissue patterning), tissue
homeostasis (wound repair and inflammatory responses), and the pathobiology of diseases …

Cells use the actin cytoskeleton for many of their functions, including their division,
adhesion, mechanosensing, endo-and phagocytosis, migration, and invasion. Actin bundles …

Fascin actin-bundling protein 1 (FSCN1) is a highly conserved actin-bundling protein that
cross links F-actin microfilaments into tight, parallel bundles. Elevated FSCN1 levels have …

Positioning and shaping the nucleus represents a mechanical challenge for the migrating
cell because of its large size and resistance to deformation. Cells shape and position the …

Laryngeal squamous cell carcinoma (LSCC) is a common form of head and neck cancer
with poor prognosis. However, the mechanism underlying the pathogenesis of LSCC …

Cell migration and invasion is a key driving factor for providing essential cellular functions
under physiological conditions or the malignant progression of tumors following downward …