Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
NTRK fusion-positive cancers and TRK inhibitor therapy
N TRK gene fusions involving either NTRK1, NTRK2 or NTRK3 (encoding the neurotrophin
receptors TRKA, TRKB and TRKC, respectively) are oncogenic drivers of various adult and …
receptors TRKA, TRKB and TRKC, respectively) are oncogenic drivers of various adult and …
BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity
P Kowiański, G Lietzau, E Czuba, M Waśkow… - Cellular and molecular …, 2018 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and
extensively studied neurotrophins in the mammalian brain. Among its prominent functions …
extensively studied neurotrophins in the mammalian brain. Among its prominent functions …
[HTML][HTML] Insulin action at a molecular level–100 years of progress
The discovery of insulin 100 years ago and its application to the treatment of human disease
in the years since have marked a major turning point in the history of medicine. The …
in the years since have marked a major turning point in the history of medicine. The …
The link between depression and chronic pain: neural mechanisms in the brain
J Sheng, S Liu, Y Wang, R Cui, X Zhang - Neural plasticity, 2017 - Wiley Online Library
Chronic pain, as a stress state, is one of the critical factors for determining depression, and
their coexistence tends to further aggravate the severity of both disorders. Unfortunately …
their coexistence tends to further aggravate the severity of both disorders. Unfortunately …
Exercise-mediated neurogenesis in the hippocampus via BDNF
PZ Liu, R Nusslock - Frontiers in neuroscience, 2018 - frontiersin.org
Exercise is known to have numerous neuroprotective and cognitive benefits, especially
pertaining to memory and learning related processes. One potential link connecting them is …
pertaining to memory and learning related processes. One potential link connecting them is …
[HTML][HTML] Brain-derived neurotrophic factor and its clinical implications
S Bathina, UN Das - Archives of medical science: AMS, 2015 - ncbi.nlm.nih.gov
Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and
growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity …
growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity …
Brain‐derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection
C Phillips - Neural plasticity, 2017 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …
growth, and maintenance of neurons in key brain circuits involved in emotional and …
Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction
Y Lu, FQ Bu, F Wang, L Liu, S Zhang, G Wang… - Translational …, 2023 - Springer
Physical exercise is of great significance for maintaining human health. Exercise can
provide varying degrees of benefits to cognitive function at all stages of life cycle. Currently …
provide varying degrees of benefits to cognitive function at all stages of life cycle. Currently …
[HTML][HTML] NTRK gene fusions as novel targets of cancer therapy across multiple tumour types
The tropomyosin receptor kinase (Trk) receptor family comprises 3 transmembrane proteins
referred to as Trk A, B and C (TrkA, TrkB and TrkC) receptors that are encoded by the …
referred to as Trk A, B and C (TrkA, TrkB and TrkC) receptors that are encoded by the …