Bacterial membrane vesicles for vaccine applications
Vaccines have been highly successful in the management of many diseases. However,
there are still numerous illnesses, both infectious and noncommunicable, for which there are …
there are still numerous illnesses, both infectious and noncommunicable, for which there are …
[HTML][HTML] Viral proteases as therapeutic targets
T Majerová, J Konvalinka - Molecular aspects of medicine, 2022 - Elsevier
Some medically important viruses―including retroviruses, flaviviruses, coronaviruses, and
herpesviruses―code for a protease, which is indispensable for viral maturation and …
herpesviruses―code for a protease, which is indispensable for viral maturation and …
Latency reversal plus natural killer cells diminish HIV reservoir in vivo
JT Kim, TH Zhang, C Carmona, B Lee, CS Seet… - Nature …, 2022 - nature.com
HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected
cells. Previous studies have shown that natural killer cells are important to inhibiting HIV …
cells. Previous studies have shown that natural killer cells are important to inhibiting HIV …
Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1
CJ Balibar, DJ Klein, B Zamlynny… - Science Translational …, 2023 - science.org
Antiretroviral therapy inhibits HIV-1 replication but is not curative due to establishment of a
persistent reservoir after virus integration into the host genome. Reservoir reduction is …
persistent reservoir after virus integration into the host genome. Reservoir reduction is …
[HTML][HTML] The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells
IL-15 is under clinical investigation toward the goal of curing HIV infection because of its
abilities to reverse HIV latency and enhance immune effector function. However, increased …
abilities to reverse HIV latency and enhance immune effector function. However, increased …
CD4+ T cells in HIV: A Friend or a Foe?
S Govindaraj, H Babu, S Kannanganat… - Frontiers in …, 2023 - frontiersin.org
Currently, there are approximately 38.4 million individuals living with the Human
Immunodeficiency Virus (HIV), of which 36.7 million adults, 1.7 million children (< 15 years …
Immunodeficiency Virus (HIV), of which 36.7 million adults, 1.7 million children (< 15 years …
Comparative immunogenicity of an mRNA/LNP and a DNA vaccine targeting HIV gag conserved elements in macaques
A Valentin, C Bergamaschi, M Rosati, M Angel… - Frontiers in …, 2022 - frontiersin.org
Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate
animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) …
animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) …
CD8+ T-cell responses in HIV controllers: potential implications for novel HIV remission strategies
RL Rutishauser, L Trautmann - Current Opinion in HIV and AIDS, 2022 - journals.lww.com
We propose implications as to how this knowledge from natural infection can be applied in
the design and evaluation of CD8+ T-cell-based remission strategies and offer questions to …
the design and evaluation of CD8+ T-cell-based remission strategies and offer questions to …
Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical …
H Mataramvura, MJ Bunders, K Duri - Frontiers in immunology, 2023 - frontiersin.org
Commencing lifelong antiretroviral therapy (ART) immediately following HIV diagnosis
(Option B+) has dramatically improved the health of HIV-infected women and their children …
(Option B+) has dramatically improved the health of HIV-infected women and their children …
Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response
A Astorga-Gamaza, J Grau-Expósito, J Burgos… - Elife, 2022 - elifesciences.org
Human immunodeficiency virus (HIV) establishes a persistent infection in heterogeneous
cell reservoirs, which can be maintained by different mechanisms including cellular …
cell reservoirs, which can be maintained by different mechanisms including cellular …