Vaccines have been highly successful in the management of many diseases. However,
there are still numerous illnesses, both infectious and noncommunicable, for which there are …

Some medically important viruses―including retroviruses, flaviviruses, coronaviruses, and
herpesviruses―code for a protease, which is indispensable for viral maturation and …

HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected
cells. Previous studies have shown that natural killer cells are important to inhibiting HIV …

Antiretroviral therapy inhibits HIV-1 replication but is not curative due to establishment of a
persistent reservoir after virus integration into the host genome. Reservoir reduction is …

IL-15 is under clinical investigation toward the goal of curing HIV infection because of its
abilities to reverse HIV latency and enhance immune effector function. However, increased …

Currently, there are approximately 38.4 million individuals living with the Human
Immunodeficiency Virus (HIV), of which 36.7 million adults, 1.7 million children (< 15 years …

Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate
animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) …

We propose implications as to how this knowledge from natural infection can be applied in
the design and evaluation of CD8+ T-cell-based remission strategies and offer questions to …

Commencing lifelong antiretroviral therapy (ART) immediately following HIV diagnosis
(Option B+) has dramatically improved the health of HIV-infected women and their children …

Human immunodeficiency virus (HIV) establishes a persistent infection in heterogeneous
cell reservoirs, which can be maintained by different mechanisms including cellular …