Thyroid autoimmunity involves loss of tolerance to thyroid proteins in genetically susceptible
individuals in association with environmental factors. In central tolerance, intrathymic …

The immunologic specificity of the antigen receptors of T cells and B cells is the result of
random shuffling of the many genes that form the DNA code for the antigen-binding site of …

Despite the sequencing of the human and mouse genomes, few genetic mechanisms for
protecting against autoimmune disease are currently known. Here we systematically screen …

Studies of repertoires of mouse monoclonal CD4+ T cells have revealed several
mechanisms of self-tolerance; however, which mechanisms operate in normal repertoires is …

Autoimmune polyendocrinopathy syndrome type 1 is a recessive Mendelian disorder
resulting from mutations in a novel gene, AIRE, and is characterized by a spectrum of organ …

T lymphocytes play a central role in regulation of the immune system. Both effector and
regulatory T cells work in equilibrium to provide optimal immune response against foreign …

Establishing effective central tolerance requires the promiscuous expression of tissue-
restricted antigens by medullary thymic epithelial cells. However, whether central tolerance …

Many human and mouse tumor antigens are normal, nonmutated tissue differentiation
antigens. Consequently, immunization with these “self” antigens could induce autoimmunity …

Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus
weak T cell receptor binding by self-peptide–MHC complexes. We find this discrimination is …

The microRNA-29 (miR-29) family is among the most abundantly expressed microRNA in
the pancreas and liver. Here, we investigated the function of miR-29 in glucose regulation …