Autophagy constitutes a mechanism for the sequestration and lysosomal degradation of
various cytoplasmic structures, including damaged organelles and invading …

The ability of neutrophils and other leucocyte members of the innate immune system to
expel their DNA into the extracellular environment in a controlled manner in order to trap …

Trehalose is a natural glucose disaccharide identified in the 19th century in fungi and insect
cocoons, and later across the three domains of life. In members of the genus …

Plants stand as an infinite and important natural resource for drug development, novel
chemotypes, pharmacophores, and other valuable bioactive agents, for a multitude of …

Background Tuberculosis (TB) causes a major burden on global health with long and
cumbersome TB treatment regimens. Host-directed immune modulating therapies have …

ABSTRACT γ9δ2 T cells provide a natural bridge between innate and adaptive immunity,
rapidly and potently respond to pathogen infection in mucosal tissues, and are prominently …

Objective/background The objective/background of this work was to study the efficacy and
safety of quercetin and polyvinylpyrrolidone (QP) in the treatment of patients with newly …

Hematogenous dissemination of Mycobacterium tuberculosis (M. tb) occurs during both
primary and reactivated tuberculosis (TB). Although hematogenous dissemination occurs in …

Aim: A 1-month Phase II trial was conducted in 41 patients with pulmonary TB who were
randomized into treatment (n= 20) and placebo (n= 21) arms to investigate the safety and …

Mycobacterium tuberculosis (Mtb) is particularly challenging for the immune system being
an intracellular pathogen, and a variety of T cell subpopulations are activated by the host …