DNA methylation markers in the postnatal developing rat brain
RK Simmons, SA Stringfellow, ME Glover, AA Wagle… - Brain research, 2013 - Elsevier
In spite of intense interest in how altered epigenetic processes including DNA methylation
may contribute to psychiatric and neurodevelopmental disorders, there is a limited …
may contribute to psychiatric and neurodevelopmental disorders, there is a limited …
Spatiotemporal specificity of correlated DNA methylation and gene expression pairs across different human tissues and stages of brain development
ABSTRACT DNA methylation (DNAm) that occurs on promoter regions is primarily
considered to repress gene expression. Previous studies indicated that DNAm could also …
considered to repress gene expression. Previous studies indicated that DNAm could also …
A saga of cancer epigenetics: linking epigenetics to alternative splicing
The discovery of an increasing number of alternative splicing events in the human genome
highlighted that∼ 94% of genes generate alternatively spliced transcripts that may produce …
highlighted that∼ 94% of genes generate alternatively spliced transcripts that may produce …
Integrative analysis of tissue-specific methylation and alternative splicing identifies conserved transcription factor binding motifs
The exact role of intragenic DNA methylation in regulating tissue-specific gene regulation is
unclear. Recently, the DNA-binding protein CTCF has been shown to participate in the …
unclear. Recently, the DNA-binding protein CTCF has been shown to participate in the …
Identification of master genes involved in liver key functions through transcriptomics and epigenomics of methyl donor deficiency in rat: relevance to nonalcoholic liver …
G Chen, J Broséus, S Hergalant… - Molecular nutrition & …, 2015 - Wiley Online Library
Scope Our study aims to investigate molecular events associated to methyl donor deficiency
(MDD) by analyzing the transcriptome and the methylome of MDD rats in liver. Methods and …
(MDD) by analyzing the transcriptome and the methylome of MDD rats in liver. Methods and …
DNA methylome analyses implicate fallopian tube epithelia as the origin for high-grade serous ovarian cancer
High-grade serous ovarian cancer (HGSC) is the most common and lethal form of epithelial
ovarian cancer (EOC). Two distinct tissues have been suggested as the tissue of origin …
ovarian cancer (EOC). Two distinct tissues have been suggested as the tissue of origin …
Thermal stress alters expression of genes involved in one carbon and DNA methylation pathways in Atlantic cod embryos
KH Skjærven, K Hamre, S Penglase, RN Finn… - … and Physiology Part A …, 2014 - Elsevier
Abstract One-carbon (1-C) metabolism is essential for normal embryonic development
through its regulation of DNA methylation and cell proliferation. With consideration to the …
through its regulation of DNA methylation and cell proliferation. With consideration to the …
Epigenetics in cardiac development, function, and disease
T Nührenberg, R Gilsbach, S Preissl, T Schnick… - Cell and tissue …, 2014 - Springer
Substantial new knowledge has accrued, over the past few years, concerning the epigenetic
regulation of heart development and disease. Epigenetic mechanisms comprise DNA …
regulation of heart development and disease. Epigenetic mechanisms comprise DNA …
CITED2 Mutation and methylation in children with congenital heart disease
M Xu, X Wu, Y Li, X Yang, J Hu, M Zheng… - Journal of Biomedical …, 2014 - Springer
Abstract Background The occurrence of Congenital Heart Disease (CHD) is resulted from
either genetic or environmental factors or the both. The CITED2 gene deletion or mutation is …
either genetic or environmental factors or the both. The CITED2 gene deletion or mutation is …
Maternal thyroid hormone programs cardiovascular functions in the offspring
M Pedaran, R Oelkrug, Q Sun, J Resch, L Schomburg… - Thyroid, 2021 - liebertpub.com
Background: Maternal thyroid hormone (TH) plays an essential role for fetal development,
especially for the cardiovascular system and its central control. However, the precise …
especially for the cardiovascular system and its central control. However, the precise …