Osteoblasts, the cells that build up our skeleton, are remarkably versatile and important cells
that need tight regulation in all the phases of their differentiation to guarantee proper skeletal …

Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

Senile osteoporosis (SOP) is widely regarded as one of the typical aging-related diseases
due to a decrease in bone mass and the destruction in microarchitecture. The inhibition of …

Age-related chronic diseases are an enormous burden to modern societies worldwide.
Among these, osteoporosis, a condition that predisposes individuals to an increased risk of …

Steroid‐induced osteoporosis (SIOP) is a form of secondary osteoporosis, but its specific
mechanism remains unclear. Glucocorticoid (GC‐)‐induced death of osteoblasts and bone …

Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass
and microarchitecture, which compromises bone strength. It is a complex multifactorial …

Purpose Osteoporosis affects more than 200 million people worldwide: its prevalence
increases with age and is actually growing due to the constant population aging. Women are …

A decline in bone mass leading to an increased fracture risk is a common feature of age-
related bone changes. The mechanisms underlying bone senescence are very complex and …

The aim of this study was to investigate the relationship between prevalence and risks of
osteoporosis or osteoporotic fracture and NAFLD. Patients with NAFLD should be monitored …

The endoplasmic reticulum (ER) is the main site for protein synthesis, folding, and secretion,
and accumulation of the unfolded/misfolded proteins in the ER may induce ER stress. ER …