Sclerostin aggravates insulin signaling in skeletal muscle and hepatic steatosis via upregulation of ER stress by mTOR‐mediated inhibition of autophagy under …
H Oh, SY Park, W Cho, AM Abd El‐Aty… - Journal of Cellular …, 2022 - Wiley Online Library
Abstract Recently, sclerostin (SCL), a circulating glycoprotein, was proposed to be a novel
myokine involved in developing metabolic disorders. The association between SCL levels …
myokine involved in developing metabolic disorders. The association between SCL levels …
[HTML][HTML] SIRT6 regulates SREBP1c-induced glucolipid metabolism in liver and pancreas via the AMPKα-mTORC1 pathway
C Bian, H Zhang, J Gao, Y Wang, J Li, D Guo… - Laboratory …, 2022 - Elsevier
The aim of this study was to determine the mechanism by which SIRT6 regulates glucolipid
metabolism disorders. We detected histological and molecular changes in Sprague-Dawley …
metabolism disorders. We detected histological and molecular changes in Sprague-Dawley …
A novel therapeutic strategy for atherosclerosis: autophagy-dependent cholesterol efflux
H Guo, D Wei, R Liu, C Zhang, S Jiang, W Wang… - Journal of physiology …, 2022 - Springer
Atherosclerosis (AS) is a chronic inflammatory disease characterized by abnormal lipid
metabolism. Foam cell formation is also known as an early event of AS. Cholesterol efflux is …
metabolism. Foam cell formation is also known as an early event of AS. Cholesterol efflux is …
[HTML][HTML] Autophagy alteration in ApoA-I related systemic amyloidosis
Amyloidoses are characterized by the accumulation and aggregation of misfolded proteins
into fibrils in different organs, leading to cell death and consequent organ dysfunction. The …
into fibrils in different organs, leading to cell death and consequent organ dysfunction. The …
[HTML][HTML] P53/miR-34a/SIRT1 positive feedback loop regulates the termination of liver regeneration
J Gong, M Cong, H Wu, M Wang, H Bai, J Wang… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Background: The capacity of the liver to restore its architecture and function assures good
prognoses of patients who suffer serious hepatic injury, cancer resection, or living donor …
prognoses of patients who suffer serious hepatic injury, cancer resection, or living donor …
Selective induction of cell death in human M1 macrophages by smac mimetics is mediated by cIAP-2 and RIPK-1/3 through the activation of mTORC
Inflammatory macrophages have been implicated in many diseases, including rheumatoid
arthritis and inflammatory bowel disease. Therefore, targeting macrophage function and …
arthritis and inflammatory bowel disease. Therefore, targeting macrophage function and …
The Prognostic Value of Serum Apolipoprotein A‐I Level and Neutrophil‐to‐Lymphocyte Ratio in Colorectal Cancer Liver Metastasis
Background. Colorectal cancer liver metastasis (CRLM) is a high degree of malignancy with
rapid disease progression and has a poor prognosis. Both serum apolipoprotein A‐I (ApoA …
rapid disease progression and has a poor prognosis. Both serum apolipoprotein A‐I (ApoA …
The DEAD‐box helicase DDX3x ameliorates non‐alcoholic fatty liver disease via mTORC1 signalling pathway
P Liu, Y Zhang, C Tang, L Cen, Y Chen, S Li… - Liver …, 2022 - Wiley Online Library
Abstract Background & Aims The DEAD (Asp‐Glu‐Ala‐Asp)‐box helicase family member
DDX3x has been proven to involve in hepatic lipid disruption during HCV infection …
DDX3x has been proven to involve in hepatic lipid disruption during HCV infection …
[HTML][HTML] An increased plasma level of ApoCIII-rich electronegative high-density lipoprotein may contribute to cognitive impairment in Alzheimer's disease
HC Chan, LY Ke, HT Lu, SF Weng, HC Chan, SH Law… - Biomedicines, 2020 - mdpi.com
High-density lipoprotein (HDL) plays a vital role in lipid metabolism and anti-inflammatory
activities; a dysfunctional HDL impairs cholesterol efflux pathways. To understand HDL's …
activities; a dysfunctional HDL impairs cholesterol efflux pathways. To understand HDL's …
白鲜碱靶向调控PI3K/KEAP1 信号抑制卵巢癌细胞增殖并诱导自噬及凋亡
吕思慧， 梁金兰， 邓明晶， 刘萤照， 王琪 - 中国癌症防治杂志, 2023 - zgazfz.com
目的探讨白鲜皮活性单体白鲜碱(Dictamnine) 对卵巢癌细胞增殖, 凋亡和自噬的影响及其作用
机制. 方法人卵巢癌细胞系(A2780, PA⁃ 1) 及人正常卵巢上皮细胞株(IOSE80) …
机制. 方法人卵巢癌细胞系(A2780, PA⁃ 1) 及人正常卵巢上皮细胞株(IOSE80) …