The progressive production and subsequent accumulation of β-amyloid (Aβ), a proteolytic
fragment of the membrane-associated amyloid precursor protein (APP), plays a central role …

Alzheimer's disease (AD) is characterized by synaptic dysfunction and cardinal
neuropathological features including amyloid plaques and neurofibrillary tangles. Soluble …

Alzheimer's disease is characterized by the aggregation and deposition of the Aβ peptide.
This 40 or 42 residue peptide is the product of the proteolysis of the amyloid precursor …

Sheds new light on intrinsically disordered proteins and peptides, including their role in
neurodegenerative diseases With the discovery of intrinsically disordered proteins and …

Extracellular deposition of amyloid‐beta (Aβ) protein, a fragment of membrane glycoprotein
called β‐amyloid precursor transmembrane protein (βAPP), is the major characteristic for the …

The C-terminus of amyloid β-protein (Aβ) 42 plays an important role in this protein's
oligomerization and may therefore be a good therapeutic target for the treatment of …

Amyloid β (Aβ) peptide accumulation in the brain is considered to be one of the hallmarks of
Alzheimer's disease. Here, we compare two analytical techniques for detecting neurotoxic …

In this study, all-atom 50 ns molecular dynamics simulations are performed on the full-length
amyloid beta (Aβ) monomers (WT-Aβ (1− 40) and WT-Aβ (1− 42)) and their oxidized forms …

In this study, the mechanism of dimerization of the full-length Alzheimer amyloid beta (Aβ42)
peptide and structural properties of the three most stable dimers have been elucidated …

Current therapeutic approaches under development for Alzheimer disease, including γ-
secretase modulating therapy, aim at increasing the production of Aβ 1–38 and Aβ 1–40 at …