Abstract Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-
inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide …

The pivotal role of lysosomes in cellular processes is increasingly appreciated. An
understanding of the balanced interplay between the activity of acidic hydrolases, lysosomal …

Metachromatic leukodystrophy is a lysosomal storage disease, which is characterized by
damage of the myelin sheath that covers most of nerve fibers of the central and peripheral …

In the first part, the following mechanisms involved in different forms of cell death are
considered, with a view to identifying potential therapeutic targets: tumour necrosis factor …

Mucopolysaccharidoses (MPSs) constitute a heterogeneous group of lysosomal storage
disorders characterized by the lysosomal accumulation of glycosaminoglycans (GAGs) …

Abstract Johann Ludwig Wilhelm Thudicum described sphingolipids (SLs) in the late
nineteenth century, but it was only in the past fifty years that SL research surged in …

Organismal aging is normally accompanied by an increase in the number of senescent cells,
growth-arrested metabolic active cells that affect normal tissue function. These cells present …

Multidrug resistance (MDR) remains a major obstacle towards curative treatment of cancer.
Despite considerable progress in delineating the basis of intrinsic and acquired MDR, the …

Lysosome imaging without perturbing intracellular activity remains challenging, as the
current commercial lysosome probes contain weakly basic amino groups that could perturb …

Objective Fabry disease is a progressive disorder caused by deficiency of the α-
galactosidase A enzyme (α-Gal A), leading to multisystemic organ damage with …