Background Despite a variety of pharmacological and device therapies for persons with
chronic heart failure (HF), prognosis and quality of life (QOL) remain poor. The need for new …

Patients with heart failure with reduced ejection fraction (HFrEF) have a high residual risk of
adverse outcomes, even when treated with optimal guideline‐directed medical therapy and …

Background This trial was designed to determine whether cardiac-resynchronization therapy
(CRT) with biventricular pacing would reduce the risk of death or heart-failure events in …

Background—Patients with chronic heart failure (HF) are at increased risk of both fatal and
nonfatal major adverse cardiovascular events. We used data from the Candesartan in Heart …

Now updated with new data and examples throughout, Clinical Epidemiology: Principles,
Methods, and Applications for Clinical Research, Second Edition is a comprehensive …

BACKGROUND: Conventional composite outcomes in heart failure (HF) trials, for example,
time to cardiovascular death or first HF hospitalization, have recognized limitations. We …

Objectives: The authors investigated the impact of coronary artery bypass grafting (CABG)
on first and recurrent hospitalization in this population. Background: In the STICH (Surgical …

BACKGROUND: In a previous metaanalysis on the approved treatments for pulmonary
hypertension, we reported that all therapies caused small changes in 6-minute walk …

Background—Eplerenone is known to reduce time to first hospitalization for heart failure or
cardiovascular death in patients with heart failure and mild symptoms. In chronic diseases …

Objective Develop and evaluate an automated identification and predictive risk report for
hospitalized heart failure (HF) patients. Methods Dictated free-text reports from the previous …