This chapter will discuss the recent literature of macrocycles and drug-like property space
moving beyond the rule of five (bRo5). Trends in chemical classes that fall within this …

This letter describes the discovery of a fused benzofuran scaffold viable for preparing a
series of novel potent HCV NS5B polymerase non-nucleoside inhibitors. Designed on the …

Hepatitis C compromises the quality of life of more than 350 million individuals worldwide.
Over the last decade, therapeutic regimens for treating hepatitis C virus (HCV) infections …

Hepatitis C virus (HCV) infection is a major worldwide problem, which involves
approximately 170 million people. High morbidity of patients is caused by chronic infection …

The discovery of a back-up to the hepatitis C virus NS3 protease inhibitor asunaprevir (2) is
described. The objective of this work was the identification of a drug with antiviral properties …

A new class of hepatitis C NS3/4A inhibitors was identified by introducing a novel spirocyclic
proline–P2 surrogate onto the P2–P4 macrocyclic core of MK-5172 (grazoprevir). The …

In this study, quantitative structure-activity relationship (QSAR) models using various
descriptor sets and training/test set selection methods were explored to predict the …

Perfluoroalkylated quinolines were efficiently synthesized via the Michael addition of
perfluoroalk-2-ynoates with isatins, followed by the reaction with alcohols through an …

Abstract The Hepatitis C Virus (HCV) NS3/4A is an attractive target for the treatment of
Hepatitis C infection. Herein, we present an investigation of HCV NS3/4A inhibitors based …

Spiro compounds provide attractive targets in drug discovery due to their inherent three-
dimensional structures, which enhance protein interactions, aid solubility and facilitate …