Pyrazolo [1, 5-a] pyrimidine-based macrocycles as novel HIV-1 inhibitors: a patent evaluation of WO2015123182
L Sun, P Gao, P Zhan, X Liu - Expert Opinion on Therapeutic …, 2016 - Taylor & Francis
The emergence of drug resistance in Combination Antiretroviral Therapy (cART) confirms a
continuing need to investigate novel HIV-1 inhibitors with unexplored mechanisms of action …
continuing need to investigate novel HIV-1 inhibitors with unexplored mechanisms of action …
A Synthesis of a Spirocyclic Macrocyclic Protease Inhibitor for the Treatment of Hepatitis C
CK Chung, E Cleator, AM Dumas, JD Hicks… - Organic …, 2016 - ACS Publications
The development of a convergent and highly stereoselective synthesis of an HCV NS3/4a
protease inhibitor possessing a unique spirocyclic and macrocyclic architecture is …
protease inhibitor possessing a unique spirocyclic and macrocyclic architecture is …
Physicochemical properties and antimicrobial activity of new spirocyclic thieno[2,3-d]pyrimidin-4(3H)-one derivatives
M de Candia, C Altamura, N Denora… - Chemistry of …, 2017 - Springer
A number of 6'-methylidene-2, 3-dihydro-1 H-spiro [pyridine-4, 5'-thieno [2, 3-d] pyrimidin]-
4'(3'H)-one derivatives, obtained as major products of a domino reaction between 5, 6, 7, 8 …
4'(3'H)-one derivatives, obtained as major products of a domino reaction between 5, 6, 7, 8 …
Understanding of the drug resistance mechanism of hepatitis C virus NS3/4A to paritaprevir due to D168N/Y mutations: A molecular dynamics simulation perspective
T Boonma, B Nutho, T Rungrotmongkol… - … biology and chemistry, 2019 - Elsevier
Abstract Hepatitis C virus (HCV) NS3/4A protease is an attractive target for the development
of antiviral therapy. However, the evolution of antiviral drug resistance is a major problem for …
of antiviral therapy. However, the evolution of antiviral drug resistance is a major problem for …
Parent 5 (7)-azachromones and their partially hydrogenated derivatives: synthesis and physicochemical properties
An approach to the preparation of hereto unknown parent 5-and 7-azachromones was
developed. The key step relied on the NaHmediated condensation of isomeric 2 (4)-acetyl-3 …
developed. The key step relied on the NaHmediated condensation of isomeric 2 (4)-acetyl-3 …
[图书][B] Drug Discovery with Privileged Building Blocks: Tactics in Medicinal Chemistry
JJ Li, M Yang - 2021 - taylorfrancis.com
Drug Discovery with Privileged Building Blocks traces back PharmaBlock's founding
philosophy of designing privileged building blocks. High-quality building blocks are crucial …
philosophy of designing privileged building blocks. High-quality building blocks are crucial …
[HTML][HTML] 丙型肝炎病毒抑制剂研究进展
宋淑， 高萍， 展鹏， 刘新泳 - 药学学报, 2020 - html.rhhz.net
丙型肝炎病毒(hepatitis C virus, HCV) 感染是全球性的公共卫生问题之一, 全世界有1.3 亿至1.5
亿人长期感染, 其中四分之一的患者会产生肝硬化, 肝细胞癌甚至肝功能衰竭等并发症 …
亿人长期感染, 其中四分之一的患者会产生肝硬化, 肝细胞癌甚至肝功能衰竭等并发症 …
PRACTICAL MULTIGRAM APPROACH TO CONFORMATIONALLY CONSTRAINED PROLINE-BASED BUILDING BLOCKS WITH GAMMA-SPIRO CONJUNCTION
I Iermolenko, O Kolosov, E Ostapchuk, D Lega… - 2024 - chemrxiv.org
Unusual amino acids have arisen as an indispensable instrument at the disposal of modern
medicinal chemistry. While extensively exploited as building blocks in the search for new …
medicinal chemistry. While extensively exploited as building blocks in the search for new …
[PDF][PDF] Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses
Y Ma, E Frutos-Beltran, D Kang… - Chemical Society …, 2021 - lirias.kuleuven.be
During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …
drug discovery culminating with the introduction of therapies able to stop human …
Targeting against HIV/HCV Co-infection using Machine Learning-based multitarget-quantitative structure-activity relationships (mt-QSAR) Methods
Y Wei, W Li, T Du, Z Hong, J Lin - bioRxiv, 2019 - biorxiv.org
Co-infection between HIV-1 and HCV is common today in certain populations. However,
treatment of co-infection is full of challenges with special consideration for potential hepatic …
treatment of co-infection is full of challenges with special consideration for potential hepatic …