The importance of time is ever prevalent in our world, and disruptions to the normal
light/dark and sleep/wake cycle have now become the norm rather than the exception for a …

Mood disorders account for a significant global disease burden, and pharmacological
innovation is needed as existing medications are suboptimal. A wide range of evidence …

Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the
quality, continuity, and timing of sleep can precipitate or exacerbate psychiatric symptoms in …

Circadian rhythm disturbance is a common feature of many psychiatric disorders. Light is the
primary input to the circadian clock, with daytime light strengthening rhythms and night-time …

Regardless of which of the mechanisms described here plays a primary or secondary role in
the pathophysiology of bipolar disorder, all of these interact to worsen clinical outcomes for …

Circadian rhythms are inherent to living organisms from single cells to humans and operate
on a genetically determined cycle of approximately 24 hours. These endogenous rhythms …

Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine
organisms. While 12 h cycles are observed in human behavior and physiology, no study has …

Background Sleep and circadian rhythm disruptions are common in patients with mood
disorders. The intricate relationship between these disruptions and mood has been …

Bipolar disorder is a relatively common mental illness, characterised by recurrent episodes
of mania (or hypomania) and major depression, and associated with a significant burden of …

Sleep and biological rhythms are integral to mood regulation across the lifespan, particularly
in bipolar disorder (BD), where alterations in sleep phase, structure, and duration occur in all …