There are virtually no clinically available neuroprotective drugs for the treatment of acute
and chronic neurological disorders, hence there is an urgent need for the development of …

Introduction: Cell-penetrating peptides (CPP) offer versatile tools for the field of drug delivery
and development of macromolecular therapeutics. These tools have matured into …

Ovarian cancer is the most lethal gynecological malignancy in the developed world. In spite
of intensive research, the mortality has hardly decreased over the past twenty years. This …

In breast cancer, the tumor microenvironment plays a critical role in the tumor progression
and responses to therapy. Tumor-associated macrophages (TAMs) are major innate …

Genetic medicine, including ribonucleic acid (RNA) therapy, has delivered numerous
progresses to the treatment of diseases thanks to the development of lipid nanoparticles …

The successful application of gene therapy relies on the development of safe and efficient
delivery vectors. Cationic polymers such as cell-penetrating peptides (CPPs) can condense …

Viral particles (VPs) have evolved so as to efficiently enter target cells and to deliver their
genetic material. The current state of knowledge allows us to use VPs in the field of …

Introduction In this study, we report on the development of an effective delivery system for
siRNAs; a novel cell-penetrating peptide (CPP), T9 (dR), obtained from transportan (TP) …

Nanoemulsions are kinetically stable colloidal systems with low viscosity. They are generally
prepared using oil and a surfactant in an aqueous medium by dispersion, producing …

Stabilized peptide therapeutics have the potential to hit currently undruggable targets,
dramatically expanding the druggable genome. However, major obstacles to their …