Chronic wounds

V Falanga, RR Isseroff, AM Soulika… - Nature Reviews …, 2022 - nature.com
Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

Microbiota and maintenance of skin barrier function

TA Harris-Tryon, EA Grice - Science, 2022 - science.org
Human skin forms a protective barrier against the external environment and is our first line of
defense against toxic, solar, and pathogenic insults. Our skin also defines our outward …

Pathogenesis, epidemiology and control of Group A Streptococcus infection

S Brouwer, T Rivera-Hernandez, BF Curren… - Nature Reviews …, 2023 - nature.com
Abstract Streptococcus pyogenes (Group A Streptococcus; GAS) is exquisitely adapted to
the human host, resulting in asymptomatic infection, pharyngitis, pyoderma, scarlet fever or …

[HTML][HTML] Nociceptor neurons affect cancer immunosurveillance

M Balood, M Ahmadi, T Eichwald, A Ahmadi… - Nature, 2022 - nature.com
Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory
peripheral nervous systems,,,–. Whether the neo-innervation of tumours by pain-initiating …

Neuromodulation by the immune system: a focus on cytokines

AF Salvador, KA de Lima, J Kipnis - Nature Reviews Immunology, 2021 - nature.com
Interactions between the immune system and the nervous system have been described
mostly in the context of diseases. More recent studies have begun to reveal how certain …

Somatosensory and autonomic neuronal regulation of the immune response

S Udit, K Blake, IM Chiu - Nature Reviews Neuroscience, 2022 - nature.com
Bidirectional communication between the peripheral nervous system (PNS) and the immune
system is a crucial part of an effective but balanced mammalian response to invading …

The dynamics of the skin's immune system

AV Nguyen, AM Soulika - International journal of molecular sciences, 2019 - mdpi.com
The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

[HTML][HTML] Somatotopic organization and intensity dependence in driving distinct NPY-expressing sympathetic pathways by electroacupuncture

S Liu, ZF Wang, YS Su, RS Ray, XH Jing, YQ Wang… - Neuron, 2020 - cell.com
The neuroanatomical basis behind acupuncture practice is still poorly understood. Here, we
used intersectional genetic strategy to ablate NPY+ noradrenergic neurons and/or adrenal …

Immune sensing of food allergens promotes avoidance behaviour

EB Florsheim, ND Bachtel, JL Cullen, BGC Lima… - Nature, 2023 - nature.com
In addition to its canonical function of protection from pathogens, the immune system can
also alter behaviour,. The scope and mechanisms of behavioural modifications by the …

[HTML][HTML] The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes

A Jacobson, D Yang, M Vella, IM Chiu - Mucosal immunology, 2021 - Elsevier
The gastrointestinal tract is densely innervated by a complex network of neurons that
coordinate critical physiological functions. Here, we summarize recent studies investigating …