Simple Summary Cell cultures can be carried out in three dimensions (3D). Organoids and
spheroids are different 3D cell culture models that can be cultured with different techniques …

Abstract The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is
becoming an essential tool in cancer research as it expresses an intermediate complexity …

Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that
stably retain key characteristics of the respective organs. Organoids can be generated from …

Vascularization of 3D models represents a major challenge of tissue engineering and a key
prerequisite for their clinical and industrial application. The use of prevascularized models …

Non-alcoholic fatty liver disease (NAFLD) represents a global healthcare challenge,
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …

Simple Summary It was found that long-established tumor-derived cell lines do not
adequately reproduce drug sensitivity and behavior of a real human cancers. Therefore …

Abstract Three-dimensional (3D) cell culture technology has been steadily studied since the
1990's due to its superior biocompatibility compared to the conventional two-dimensional …

Background An impressive percentage of biomedical advances were achieved through
animal research and cell culture investigations. For drug testing and disease researches …

Organ on chip (OOC) has emerged as a major technological breakthrough and distinct
model system revolutionizing biomedical research and drug discovery by recapitulating the …

Background Resistance to oxaliplatin is a major obstacle for the management of locally
advanced and metastatic colon cancer (CC). Although long noncoding RNAs (lncRNAs) …