JAK inhibitors in the treatment of atopic dermatitis

R Chovatiya, AS Paller - Journal of Allergy and Clinical Immunology, 2021 - Elsevier
Atopic dermatitis (AD) is a chronic inflammatory skin disorder associated with heterogenous
presentation and often immense patient burden. Safe, targeted treatment options are …

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy

BJH Dierick, T van der Molen… - Expert review of …, 2020 - Taylor & Francis
Introduction Asthma, allergic rhinitis, atopic dermatitis, and food allergy affect approximately
20% of the global population. Few studies describe the burden of the totality of these …

[HTML][HTML] Efficacy and safety of ruxolitinib cream for the treatment of atopic dermatitis: results from 2 phase 3, randomized, double-blind studies

K Papp, JC Szepietowski, L Kircik, D Toth… - Journal of the American …, 2021 - Elsevier
Background Ruxolitinib (RUX) cream demonstrated potent anti-inflammatory and antipruritic
efficacy in a phase 2 study in adults with atopic dermatitis (AD). Objective To evaluate 8 …

Efficacy and safety of abrocitinib in patients with moderate-to-severe atopic dermatitis: a randomized clinical trial

JI Silverberg, EL Simpson, JP Thyssen… - JAMA …, 2020 - jamanetwork.com
Importance Abrocitinib, an oral, once-daily Janus kinase 1 selective inhibitor, was effective
and well tolerated in a phase 3 monotherapy trial of patients with moderate-to-severe atopic …

[HTML][HTML] Prevalence and incidence of atopic dermatitis: a systematic review

S Bylund, LB von Kobyletzki, M Svalstedt… - Acta dermato …, 2020 - ncbi.nlm.nih.gov
The primary objective of this study was to systematically review and analyse epidemiological
studies of the prevalence and incidence of atopic dermatitis (AD) during childhood and …

Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis

H He, H Suryawanshi, P Morozov… - Journal of Allergy and …, 2020 - Elsevier
Background Atopic dermatitis (AD) is a prevalent inflammatory skin disease with a complex
pathogenesis involving immune cell and epidermal abnormalities. Despite whole tissue …

Classification of human chronic inflammatory skin disease based on single-cell immune profiling

Y Liu, H Wang, M Taylor, C Cook… - Science …, 2022 - science.org
Inflammatory conditions represent the largest class of chronic skin disease, but the
molecular dysregulation underlying many individual cases remains unclear. Single-cell RNA …

[HTML][HTML] The epidemiology and global burden of atopic dermatitis: a narrative review

HA Hadi, AI Tarmizi, KA Khalid, M Gajdács, A Aslam… - Life, 2021 - mdpi.com
The global epidemiology of atopic dermatitis (AD) in the current decade (2009–2019) has
not been extensively reported. Epidemiological studies play an important role in presenting …

American Academy of Dermatology Guidelines: awareness of comorbidities associated with atopic dermatitis in adults

DMR Davis, AM Drucker, A Alikhan, L Bercovitch… - Journal of the American …, 2022 - Elsevier
Background Studies found associations between atopic dermatitis (AD) and various
comorbidities. Objective To appraise evidence of the association between AD and …

Comorbidities and the impact of atopic dermatitis

JI Silverberg - Annals of Allergy, Asthma & Immunology, 2019 - Elsevier
Objective Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease with
substantial patient and population burdens. A number of comorbid health problems occur in …