Spesolimab, an anti‐interleukin‐36 receptor antibody, in patients with moderate‐to‐severe atopic dermatitis: Results from a multicentre, randomized, double‐blind …

R Bissonnette, W Abramovits… - Journal of the …, 2023 - Wiley Online Library
Background Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease, and
there is increasing evidence that the interleukin (IL)‐36 pathway may play a role in the …

Real‐world experience of dupilumab treatment for atopic dermatitis in adults: a retrospective analysis of patients' records

C Wang, CN Kraus, KG Patel… - International Journal …, 2020 - Wiley Online Library
Background Clinical trial data for dupilumab, a monoclonal antibody against the interleukin‐
4 receptor (IL‐4Rα), have shown that it is safe and effective for the treatment of moderate to …

Patient‐reported outcomes from the JADE COMPARE randomized phase 3 study of abrocitinib in adults with moderate‐to‐severe atopic dermatitis

JP Thyssen, G Yosipovitch, C Paul… - Journal of the …, 2022 - Wiley Online Library
Abstract Background In JADE COMPARE, abrocitinib improved severity of atopic dermatitis
(AD) and demonstrated rapid itch relief. Objectives We examined clinically meaningful …

Diagnosing atopic dermatitis in skin of color

W Adawi, H Cornman, A Kambala, S Henry… - Dermatologic …, 2023 - derm.theclinics.com
Atopic Dermatitis (AD) is an extremely pruritic inflammatory skin disease that has a
worldwide prevalence of approximately 2.69%, with significant variability by country. 1 In the …

Rademikibart (CBP‐201), a next‐generation monoclonal antibody targeting human IL‐4Rα: Two phase I randomized trials, in healthy individuals and patients with …

J Wang, J White, KJ Sansone… - Clinical and …, 2023 - Wiley Online Library
Abstract IL‐4 and IL‐13 signaling via IL‐4Rα plays key roles in the pathogenesis of atopic
dermatitis (AD) and asthma. Rademikibart (formerly CBP‐201), a next‐generation human …

The efficacy and safety of IL-13 inhibitors in atopic dermatitis: A systematic review and meta-analysis

Y Zhang, D Jing, J Cheng, X Chen, M Shen… - Frontiers in …, 2022 - frontiersin.org
Background Several clinical trials have evaluated the efficacy and safety of interleukin-13 (IL-
13) with lebrikizumab and tralokinumab in patients with moderate to severe atopic dermatitis …

Adult-onset atopic dermatitis: characteristics and management

PP Vakharia, JI Silverberg - American Journal of Clinical Dermatology, 2019 - Springer
Recent epidemiological studies found the US prevalence of atopic dermatitis in adults to be
approximately 7%. In particular, one in four adults with atopic dermatitis report adult onset of …

Distribution of atopic dermatitis lesions in United States adults

JI Silverberg, DJ Margolis… - Journal of the …, 2019 - Wiley Online Library
Background The distribution of atopic dermatitis (AD) lesions and its impact on quality of life
(QOL) is not well established in the US adult population. Objective To elucidate the …

Accurate diagnosis of atopic dermatitis by combining transcriptome and microbiota data with supervised machine learning

Z Jiang, J Li, N Kong, JH Kim, BS Kim, MJ Lee… - Scientific reports, 2022 - nature.com
Atopic dermatitis (AD) is a common skin disease in childhood whose diagnosis requires
expertise in dermatology. Recent studies have indicated that host genes–microbial …

Prevalence and characteristics of atopic dermatitis among young adult females and males—report from the Swedish population‐based study BAMSE

EK Johansson, A Bergström, I Kull… - Journal of the …, 2022 - Wiley Online Library
Background There is limited knowledge regarding prevalence and characteristics of atopic
dermatitis (AD) among young adults in the general population. Objectives To study AD …