Cardiac development and function are becoming increasingly well understood from different
angles, including signalling, transcriptional and epigenetic mechanisms. By contrast, the …

RNA splicing is an important RNA processing step required by multiexon protein-coding
mRNAs and some noncoding RNAs. Precise RNA splicing is required for maintaining gene …

Alternative splicing generates specialized protein isoforms that allow the heart to adapt
during development and disease. The recent discovery that mutations in the splicing factor …

Myotonic dystrophy type 1 (DM1) is a genetic disorder that causes muscle weakness and
myotonia. In DM1 patients, cardiac electrical manifestations include conduction defects and …

RNA binding proteins (RBPs) play a central in the post-transcriptional regulation of gene
expression, which can account for up to 50% of all variations in protein expression within a …

The post-transcriptional regulation of gene expression plays an important role in heart
development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding …

Background Many genomic imprinting left during long-term selective evolution may drive the
formation of important economical traits of introduced and indigenous sheep breeds …

La dystrophie myotonique de type 1 (DM1) est une maladie rare héréditaire avec des
atteintes musculaires, cardiaques et cognitives. La DM1 est due à des expansions de …