Inactivation Mechanisms of Escherichia coli in Simulants of Respiratory and Environmental Aerosol Droplets

M Otero-Fernandez, RJ Thomas, H Oswin, R Alexander… - Atmosphere, 2024 - mdpi.com
The airborne transmission of disease relies on the ability of microbes to survive aerosol
transport and, subsequently, cause infection when interacting with a host. The length of time …

[HTML][HTML] Visible and UVA light as a potential means of preventing Escherichia coli biofilm formation in urine and on materials used in urethral catheters

TL Vollmerhausen, A Conneely, C Bennett… - … of Photochemistry and …, 2017 - Elsevier
Catheter-associated urinary tract infections are the most common hospital-acquired
infection, for which Escherichia coli is the leading cause. This study investigated the efficacy …

N-Chlorotaurine, a Promising Future Candidate for Topical Therapy of Fungal Infections

M Nagl, R Arnitz, M Lackner - Mycopathologia, 2018 - Springer
N-Chlorotaurine (NCT) is a mild long-lived oxidant that can be applied to sensitive body
regions as an endogenous antiseptic. Enhancement of its microbicidal activity in the …

Membrane phospholipid composition of Pseudomonas aeruginosa grown in a cystic fibrosis mucus-mimicking medium

E Deschamps, A Schaumann, I Schmitz-Afonso… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background Pseudomonas aeruginosa is a bacterium able to induce serious pulmonary
infections in cystic fibrosis (CF) patients. This bacterium is very often antibiotic resistant …

Secondary messenger signalling influences Pseudomonas aeruginosa adaptation to sinus and lung environments

D Ruhluel, L Fisher, TE Barton, H Leighton… - The ISME …, 2024 - academic.oup.com
Pseudomonas aeruginosa is a cause of chronic respiratory tract infections in people with
cystic fibrosis (CF), non-CF bronchiectasis, and chronic obstructive pulmonary disease …

Investigating the biological properties of carbohydrate derived fulvic acid (CHD-FA) as a potential novel therapy for the management of oral biofilm infections

L Sherry, E Millhouse, DF Lappin, C Murray, S Culshaw… - BMC Oral Health, 2013 - Springer
Background A number of oral diseases, including periodontitis, derive from microbial
biofilms and are associated with increased antimicrobial resistance. Despite the widespread …

Esculentin-1a derived antipseudomonal peptides: limited induction of resistance and synergy with aztreonam

B Casciaro, MR Loffredo, V Luca… - Protein and Peptide …, 2018 - ingentaconnect.com
Background: The massive use of antibiotics has led to the selection of resistant bacterial
strains that are difficult to eradicate. Among these, Pseudomonas aeruginosa most …

Antibiotic efficacy testing in an ex vivo model of Pseudomonas aeruginosa and Staphylococcus aureus biofilms in the cystic fibrosis lung

NE Harrington, E Sweeney, I Alav, F Allen… - JoVE (Journal of …, 2021 - jove.com
The effective prescription of antibiotics for the bacterial biofilms present within the lungs of
individuals with cystic fibrosis (CF) is limited by a poor correlation between antibiotic …

Bactericidal and Fungicidal Activity of N-Chlorotaurine Is Enhanced in Cystic Fibrosis Sputum Medium

M Gruber, I Moser, M Nagl… - Antimicrobial Agents and …, 2017 - Am Soc Microbiol
Lung infections with multiresistant pathogens are a major problem among patients suffering
from cystic fibrosis (CF). N-Chlorotaurine (NCT), a microbicidal active chlorine compound …

The Efficacy of an N-Acetylcysteine–Antibiotic Combination Therapy on Achromobacter xylosoxidans in a Cystic Fibrosis Sputum/Lung Cell Model

A Aiyer, T Das, GS Whiteley, T Glasbey, FH Kriel… - Biomedicines, 2022 - mdpi.com
Cystic fibrosis (CF) is a disorder causing dysfunctional ion transport resulting in the
accumulation of viscous mucus. This environment fosters a chronic bacterial biofilm …