Amorphous solid dispersions (ASDs) are a formulation and development strategy that can
be used to increase the apparent aqueous solubility of poorly water-soluble drugs. Their …

Does the performance of an amorphous solid dispersion rely on having 100% amorphous
content? What specifications are appropriate for crystalline content within an amorphous …

Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …

Preventing crystallization is a primary concern when developing amorphous drug
formulations. Recently, atomic layer coatings (ALCs) of aluminum oxide demonstrated …

Low concentration polymer additives can significantly alter crystal growth kinetics of
molecular liquids and glasses. However, the effect of polymer concentration on nucleation …

A thorough understanding of effects of polymers on crystallization of amorphous drugs is
essential for rational design of robust amorphous solid dispersion (ASD), since …

This work aimed to develop and characterize a water-soluble, high-release active
pharmaceutical ingredient (API) composite based on the practically water-insoluble API N …

The R 3 m molecular descriptor (R-GETAWAY third-order autocorrelation index weighted by
the atomic mass) has previously been shown to encode molecular attributes that appear to …

Introduction. Limited aqueous solubility and subsequent poor absorption and low
bioavailability are the main challenges in oral drug delivery. Solid dispersion is a widely …

This paper reviews the structure and properties of amorphous active pharmaceutical
ingredients (APIs), including small molecules and proteins, in the glassy state (below the …