Potential benefits of antioxidant phytochemicals in type 2 diabetes

A Arabshomali, S Bazzazzadehgan, F Mahdi… - Molecules, 2023 - mdpi.com
The clinical relationship between diabetes and inflammation is well established. Evidence
clearly indicates that disrupting oxidant-antioxidant equilibrium and elevated lipid …

Pharmacological activities and therapeutic potential of galangin, a promising natural flavone, in age-related diseases

F Zhang, Y Yan, LM Zhang, DX Li, L Li, WW Lian… - Phytomedicine, 2023 - Elsevier
Background The extension of average life expectancy and the aggravation of population
aging have become the inevitable trend of human development. In an aging society, various …

Formononetin ameliorates renal dysfunction, oxidative stress, inflammation, and apoptosis and upregulates Nrf2/HO-1 signaling in a rat model of gentamicin-induced …

OY Althunibat, MH Abukhalil, SH Aladaileh… - Frontiers in …, 2022 - frontiersin.org
Gentamicin (GEN) is a bactericidal aminoglycoside known to cause nephrotoxicity.
Formononetin (FN) is a potent flavonoid that exhibits numerous promising pharmacological …

Upregulation of Nrf2/HO-1 signaling and attenuation of oxidative stress, inflammation, and cell death mediate the protective effect of apigenin against …

W Al-Amarat, MH Abukhalil, RS Alruhaimi, HA Alqhtani… - Metabolites, 2022 - mdpi.com
Liver injury is among the adverse effects of the chemotherapeutic agent cyclophosphamide
(CP). This study investigated the protective role of the flavone apigenin (API) against CP …

Femtosecond laser attenuates oxidative stress, inflammation, and liver fibrosis in rats: Possible role of PPARγ and Nrf2/HO-1 signaling

AE Mohamed, AM Mahmoud, WR Mohamed… - Life Sciences, 2022 - Elsevier
Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) proteins that occurs
in chronic liver injury. Inflammation and oxidative stress play a key role in fibrogenesis which …

Galangin mitigates DOX-induced cognitive impairment in rats: Implication of NOX-1/Nrf-2/HMGB1/TLR4 and TNF-α/MAPKs/RIPK/MLKL/BDNF

SA Abd El-Aal, M AbdElrahman, AM Reda, H Afify… - Neurotoxicology, 2022 - Elsevier
The cognitive and behavioral decline observed in cancer survivors who underwent
doxorubicin (DOX)-based treatment raises the need for therapeutic interventions to …

Renoprotective and oxidative stress-modulating effects of taxifolin against cadmium-induced nephrotoxicity in mice

AI Algefare - Life, 2022 - mdpi.com
Cadmium (Cd) is an inessential trace metal that accumulates in the kidney and may lead to
renal toxicity by mediating oxidative stress (OS), inflammatory reactions, and apoptosis. The …

Omarigliptin/galangin combination mitigates lipopolysaccharide-induced neuroinflammation in rats: Involvement of glucagon-like peptide-1, toll-like receptor-4 …

AM Kabel, HH Arab, A Atef, RS Estfanous - Life Sciences, 2022 - Elsevier
Aims The objectives of this work were to assess the possibility of administration of
omarigliptin and/or galangin to combat lipopolysaccharide (LPS)-induced …

[PDF][PDF] Upregulation of Nrf2/HO-1 signaling and attenuation of oxidative stress, inflammation, and cell death mediate the protective effect of apigenin against …

W Al-Amarat, MH Abukhalil, RS Alruhaimi… - DOI: https://doi. org …, 2022 - academia.edu
Liver injury is among the adverse effects of the chemotherapeutic agent cyclophosphamide
(CP). This study investigated the protective role of the flavone apigenin (API) against CP …

Protective effects of chlorogenic acid against carbon tetrachloride-induced hepatotoxicity in mice

YW Hsu, YY Chen, CF Tsai - Processes, 2021 - mdpi.com
The protective effects of chlorogenic acid (CGA) against liver injury were evaluated by its
reduction in carbon tetrachloride (CCl4)-induced hepatic damage in ICR mice. The animals …