Curcumin: an inflammasome silencer

S Hasanzadeh, MI Read, AR Bland, M Majeed… - Pharmacological …, 2020 - Elsevier
Curcumin is the major bioactive polyphenolic ingredient of turmeric. Increasing evidence
indicates that the health benefits of curcumin are mediated through its anti-inflammatory and …

[HTML][HTML] Bioactivity, health benefits, and related molecular mechanisms of curcumin: Current progress, challenges, and perspectives

XY Xu, X Meng, S Li, RY Gan, Y Li, HB Li - Nutrients, 2018 - mdpi.com
Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used
as a spice in cooking and a yellow pigment in the food processing industry. Recent studies …

A review of therapeutic potentials of turmeric (Curcuma longa) and its active constituent, curcumin, on inflammatory disorders, pain, and their related patents

BM Razavi, M Ghasemzadeh Rahbardar… - Phytotherapy …, 2021 - Wiley Online Library
Turmeric (Curcuma longa) and its constituent, curcumin, have been used for their
therapeutic properties for a long time. Most of the medicinal impacts of turmeric and …

The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids

L Kooshki, SN Zarneshan, S Fakhri, SZ Moradi… - Phytomedicine, 2023 - Elsevier
Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …

Role of miRNAs in diabetic neuropathy: mechanisms and possible interventions

P Kaur, S Kotru, S Singh, A Munshi - Molecular neurobiology, 2022 - Springer
Accelerating cases of diabetes worldwide have given rise to higher incidences of diabetic
complications. MiRNAs, a much-explored class of non-coding RNAs, play a significant role …

[HTML][HTML] Topical curcumin nanocarriers are neuroprotective in eye disease

BM Davis, M Pahlitzsch, L Guo, S Balendra, P Shah… - Scientific reports, 2018 - nature.com
Abstract Curcumin (1, 7-bis-(4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5dione) is a
polyphenol extracted from turmeric that has long been advocated for the treatment of a …

Role of curcumin in the management of pathological pain

J Sun, F Chen, C Braun, YQ Zhou, H Rittner, YK Tian… - Phytomedicine, 2018 - Elsevier
Background: Pathological pain conditions can be triggered after peripheral nerve injury
and/or inflammation. It is a major clinical problem that is poorly treated with available …

[HTML][HTML] Natural products: evidence for neuroprotection to be exploited in glaucoma

A Adornetto, L Rombolà, LA Morrone, C Nucci… - Nutrients, 2020 - mdpi.com
Glaucoma, a leading cause of irreversible blindness worldwide, is an optic neuropathy
characterized by the progressive death of retinal ganglion cells (RGCs). Elevated intraocular …

COVID‐19: A case for inhibiting NLRP3 inflammasome, suppression of inflammation with Curcumin?

A Saeedi‐Boroujeni… - Basic & Clinical …, 2021 - Wiley Online Library
Curcumin is the effective ingredient of turmeric, sometimes used as a painkiller in traditional
medicine. It has extensive biological properties such as anti‐inflammatory and antioxidant …

Curcumin attenuates inflammation and cell apoptosis through regulating NF-κB and JAK2/STAT3 signaling pathway against acute kidney injury

H Zhu, X Wang, X Wang, B Liu, Y Yuan, X Zuo - Cell Cycle, 2020 - Taylor & Francis
Curcumin alleviates septic acute kidney injury (SAKI); however, the underlying mechanism
remained unclear. To explore this, SAKI cell model and mice model were conducted by …