Isobaric labeling-based relative quantification in shotgun proteomics

N Rauniyar, JR Yates III - Journal of proteome research, 2014 - ACS Publications
Mass spectrometry plays a key role in relative quantitative comparisons of proteins in order
to understand their functional role in biological systems upon perturbation. In this review, we …

Analysis of the plasma proteome using iTRAQ and TMT‐based Isobaric labeling

R Moulder, SD Bhosale, DR Goodlett… - Mass spectrometry …, 2018 - Wiley Online Library
Over the past decade, chemical labeling with isobaric tandem mass tags, such as isobaric
tags for relative and absolute quantification reagents (iTRAQ) and tandem mass tag (TMT) …

[HTML][HTML] Mass spectrometry-assisted gel-based proteomics in cancer biomarker discovery: approaches and application

R Huang, Z Chen, L He, N He, Z Xi, Z Li, Y Deng… - Theranostics, 2017 - ncbi.nlm.nih.gov
There is a critical need for the discovery of novel biomarkers for early detection and targeted
therapy of cancer, a major cause of deaths worldwide. In this respect, proteomic …

[HTML][HTML] Gut mucosal proteins and bacteriome are shaped by the saturation index of dietary lipids

N Abulizi, C Quin, K Brown, YK Chan, SK Gill… - Nutrients, 2019 - mdpi.com
The dynamics of the tripartite relationship between the host, gut bacteria and diet in the gut
is relatively unknown. An imbalance between harmful and protective gut bacteria, termed …

Proteomic advances in salivary diagnostics

E Pappa, K Vougas, J Zoidakis, H Vastardis - Biochimica et Biophysica Acta …, 2020 - Elsevier
Saliva is identified as functional equivalent to serum, reflecting the physiological state of the
body, as well as hormonal, emotional, nutritional and metabolic alterations. The application …

A comparative proteomic study of human skin suction blister fluid from healthy individuals using immunodepletion and iTRAQ labeling

AC Müller, FP Breitwieser, H Fischer… - Journal of proteome …, 2012 - ACS Publications
Aberrations in skin morphology and functionality can cause acute and chronic skin-related
diseases that are the focus of dermatological research. Mechanically induced skin suction …

[HTML][HTML] Proteomics for prediction of disease progression and response to therapy in diabetic kidney disease

MJ Pena, H Mischak, HJL Heerspink - Diabetologia, 2016 - Springer
The past decade has resulted in multiple new findings of potential proteomic biomarkers of
diabetic kidney disease (DKD). Many of these biomarkers reflect an important role in the …

Serum proteomes distinguish children developing type 1 diabetes in a cohort with HLA-conferred susceptibility

R Moulder, SD Bhosale, T Erkkilä, E Laajala, J Salmi… - Diabetes, 2015 - Am Diabetes Assoc
We determined longitudinal serum proteomics profiles from children with HLA-conferred
diabetes susceptibility to identify changes that could be detected before seroconversion and …

Mass spectrometry-based proteomic quest for diabetes biomarkers

S Shao, T Guo, R Aebersold - … et Biophysica Acta (BBA)-Proteins and …, 2015 - Elsevier
Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia,
which affects hundreds of millions of individuals worldwide. Early diagnosis and …

Beneficial effects of phlorizin on diabetic nephropathy in diabetic db/db mice

F Pei, B Li, Z Zhang, F Yu, X Li, Q Cai, H Gao… - Journal of Diabetes and …, 2014 - Elsevier
Aims This study observes the effects of phlorizin on diabetic nephrology in db/db diabetic
mice and explores possible underlying mechanisms. Methods Sixteen diabetic db/db mice …