The efficient study of human disease requires the proper tools, one of the most crucial of
which is an accurate animal model that faithfully recapitulates the human condition. The …

Studies on the neuroprotective and promyelinating effects of progesterone in the nervous
system are of great interest due to their potential clinical connotations. In peripheral …

The identification of novel molecular targets crucially involved in motor neuron
degeneration/survival is a necessary step for the development of hopefully more effective …

The biosynthetic sorting of acid hydrolases to lysosomes relies on transmembrane,
mannose 6-phosphate receptors (MPRs) that cycle between the TGN and endosomes …

This review article is focused on the research progress made utilizing the wobbler mouse as
animal model for human motor neuron diseases, especially the amyotrophic lateral sclerosis …

Toll-like receptors (TLRs) are best known for recognizing pathogens and initiating an innate
immune response to protect the host. However, they also detect tissue damage and induce …

Molecular techniques allowing in vivo modulation of gene expression have provided unique
opportunities and challenges for behavioural studies aimed at understanding the function of …

Numerous mutations that impair retrograde membrane trafficking between endosomes and
the Golgi apparatus lead to neurodegenerative diseases. For example, mutations in the …

Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disease of the central
nervous system. Symptomatic and presymptomatic ALS patients demonstrate cortical …

The Golgi associated retrograde protein complex (GARP) is an evolutionarily conserved
component of Golgi membrane trafficking machinery that belongs to the Complexes …