Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
motor neuron degeneration in the central nervous system. Recent research has increasingly …

Background: Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease
characterized by the loss of motor neurons in cerebral cortex, brainstem and spinal cord …

In the Wobbler mouse, a mutation in the Vps54 gene is accompanied by motoneuron
degeneration and astrogliosis in the cervical spinal cord. Previous work has shown that …

Patients suffering of amyotrophic lateral sclerosis (ALS) present motoneuron degeneration
leading to muscle atrophy, dysphagia, and dysarthria. The Wobbler mouse, an animal model …

Phosphoprotein enriched in astrocytes of 15 kDa (PEA-15) is an abundant phosphoprotein
in primary cultures of mouse brain astrocytes. Its capability to interact with members of the …

Introduction Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
whose aetiology is unknown. It is characterised by upper and lower motor neuron …

The Wobbler mouse has been proposed as an experimental model of the sporadic form of
amyotrophic lateral sclerosis (ALS). The administration of natural progesterone (PROG) to …

VPS54 is a component of the Golgi-associated retrograde protein (GARP) complex of
vesicle sorting proteins. A missense mutation of Vps54 is responsible for motor neuron …

Previous work demonstrated that progesterone (PROG) treatment attenuates morphological,
molecular and functional abnormalities in the spinal cord of the Wobbler (Wr) mouse, a …

One of the most striking physiological features of skeletal muscle tissues are their enormous
capacity to adapt to changed functional demands. Muscle plasticity has been extensively …