Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome
signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen …

Highlights•Ovarian cancer is a major cause of mortality and case numbers are
increasing.•Five-year relative survival is below 45%.•Reproductive exposures strongly …

Purpose An understanding of the etiologic heterogeneity of ovarian cancer is important for
improving prevention, early detection, and therapeutic approaches. We evaluated 14 …

The relationship between inflammation and cancer has been recognized since the 17th
century, 1 and we now know much about the cells, cytokines and physiological processes …

There has been much effort recently to probe the long-recognized relationship between the
pathological processes of infection, inflammation and cancer. For example, epidemiological …

In a healthy body, ROS (reactive oxygen species) and antioxidants remain in balance. When
the balance is disrupted towards an overabundance of ROS, oxidative stress (OS) occurs …

Human papillomaviruses (HPVs), which belong to the Papillomaviridae family, constitute a
group of small nonenveloped double-stranded DNA viruses. HPV has a small genome that …

Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high
ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that …

Ovarian cancers represent the deadliest among gynecologic malignancies and are
characterized by a hierarchical structure with cancer stem cells (CSCs) endowed with self …

The objective of this study was to identify and characterize a self-renewing subpopulation of
human ovarian tumor cells (ovarian cancer-initiating cells, OCICs) fully capable of serial …