Novel experimental approaches such as fate-mapping and single-cell analysis have brought
fresh insight into monocyte development and function over the past decade and helped …

The burgeoning field of leukocyte trafficking has created new and exciting opportunities in
the clinic. Trafficking signals are being defined that finely control the movement of distinct …

The chemokine receptor CCR2 plays a vital role for the induction of autoimmunity in the
central nervous system. However, it remains unclear how the pathogenic response is …

Structural analysis of modern pharmaceutical practices allows for the identification of two
rapidly growing trends: the introduction of tailor‐made amino acids and the exploitation of …

Chemotaxis, the movement of cells along chemical gradients, is critical for the recruitment of
immune cells to sites of inflammation; however, how cells navigate in chemotactic gradients …

The infiltration of leukocytes into the central nervous system (CNS) is an essential step in the
neuropathogenesis of multiple sclerosis (MS). Leukocyte extravasation from the …

Review of pro-and anti-inflammatory cytokines, and their dependence on the local
concentration of a given cytokine, the stage of disease in which it is administered, and its …

Myeloid cells are mediators of central nervous system (CNS) damage and recovery in
neuroinflammatory and neurodegenerative disorders. Besides endogenous myelomonocytic …

The clinical picture of experimental autoimmune encephalomyelitis (EAE) is critically
dependent on the nature of the target autoantigen and the genetic background of the …

purpose. To characterize the reactions of retinal glial cells (astrocytes and Müller cells) to
retinal injury in mice that lack glial fibrillary acidic protein (GFAP) and vimentin (GFAP …