Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell
undergoes a series of molecular events that lead to a change in phenotype toward a …

Angiogenesis is a highly coordinated process of formation of new blood vessels from pre-
existing blood vessels. The process of development of the proper vascular network is a …

Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …

Formation of blood vessel networks by sprouting angiogenesis is critical for tissue growth,
homeostasis and regeneration. How endothelial cells arise in adequate numbers and …

Mechanical forces regulate multiple essential pathways in the cell. The nuclear translocation
of mechanoresponsive transcriptional regulators is an essential step for …

Angiogenesis and vascular remodeling are essential for the establishment of vascular
networks during organogenesis. Here we show that the Hippo signaling pathway effectors …

The valves of the heart are crucial for ensuring that blood flows in one direction from the
heart, through the lungs and back to the rest of the body. Heart valve development is …

The vascular system is critical for developmental growth, tissue homeostasis and repair but
also for tumor development. Bone morphogenetic protein (BMP) signaling has recently …

The process named endothelial‐to‐mesenchymal transition (EndMT) was observed for the
first time during the development of the chicken embryo several decades ago. Of interest …

Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
are the downstream effectors of the Hippo signaling pathway that play a crucial role in …