Sepsis associated acute kidney injury

JT Poston, JL Koyner - Bmj, 2019 - bmj.com
Sepsis is defined as organ dysfunction resulting from the host's deleterious response to
infection. One of the most common organs affected is the kidneys, resulting in sepsis …

Extracellular DNA traps in inflammation, injury and healing

C Daniel, M Leppkes, LE Muñoz, G Schley… - Nature Reviews …, 2019 - nature.com
Following strong activation signals, several types of immune cells reportedly release
chromatin and granular proteins into the extracellular space, forming DNA traps. This …

Post-treatment With Irisin Attenuates Acute Kidney Injury in Sepsis Mice Through Anti-Ferroptosis via the SIRT1/Nrf2 Pathway

Z Qiongyue, Y Xin, P Meng, M Sulin, W Yanlin… - Frontiers in …, 2022 - frontiersin.org
Kidney is one of the most vulnerable organs in sepsis, resulting in sepsis-associated acute
kidney injury (SA-AKI), which brings about not only morbidity but also mortality of sepsis …

Ginsenoside Rg1 ameliorates sepsis-induced acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells

J Guo, R Wang, F Min - Journal of Leukocyte Biology, 2022 - academic.oup.com
Acute kidney injury (AKI) represents a prevailing complication of sepsis, and its onset
involves ferroptosis. Ginsenoside Rg1 exerts a positive effect on kidney diseases. This study …

Management of hepatorenal syndrome in liver cirrhosis: a recent update

C Bera, F Wong - Therapeutic advances in gastroenterology, 2022 - journals.sagepub.com
Hepatorenal syndrome (HRS) is a serious form of renal dysfunction in patients with cirrhosis
and ascites. It is an important component of the acute-on-chronic liver failure (ACLF) …

Evidence for and against direct kidney infection by SARS-CoV-2 in patients with COVID-19

L Hassler, F Reyes, MA Sparks… - Clinical Journal of the …, 2021 - journals.lww.com
Despite evidence of multiorgan tropism of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) in patients with coronavirus disease 2019 (COVID-19), direct viral kidney …

Fatty acid-binding protein 4 is a therapeutic target for septic acute kidney injury by regulating inflammatory response and cell apoptosis

B Wang, J Xu, Q Ren, L Cheng, F Guo, Y Liang… - Cell Death & …, 2022 - nature.com
Sepsis is a systemic inflammatory state in response to infection, and concomitant acute
kidney injury (AKI) significantly increases morbidity and mortality. Growing evidence …

Enhanced efficiency of mitochondria-targeted peptide SS-31 for acute kidney injury by pH-responsive and AKI-kidney targeted nanopolyplexes

D Liu, F Jin, G Shu, X Xu, J Qi, X Kang, H Yu, K Lu… - Biomaterials, 2019 - Elsevier
Oxidative stress is an important pathological mechanism for acute kidney injury (AKI). SS-31,
as a mitochondria-targeted peptide with strong antioxidant activity, is a good candidate for …

[HTML][HTML] Sepsis-mediated renal dysfunction: pathophysiology, biomarkers and role of phytoconstituents in its management

A Balkrishna, S Sinha, A Kumar, V Arya… - Biomedicine & …, 2023 - Elsevier
Sepsis has evolved as an enormous health issue amongst critically ill patients. It is a major
risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) is one of …

[HTML][HTML] NOX4 is a potential therapeutic target in septic acute kidney injury by inhibiting mitochondrial dysfunction and inflammation

J Li, L Wang, B Wang, Z Zhang, L Jiang, Z Qin… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: Sepsis is a severe clinical syndrome featured through organ dysfunction due to
infection, while the accompanying acute kidney injury (AKI) is linked to significant incidence …