From allergen structure to new forms of allergen-specific immunotherapy
R Valenta, D Kraft - Current opinion in immunology, 2002 - Elsevier
During the past decade, genetic information for most of the common allergens has been
obtained. Using these genetic blueprints it has become possible to reconstruct, by …
obtained. Using these genetic blueprints it has become possible to reconstruct, by …
The Immunoglobulin E–Allergen Interaction: A Target for Therapy of Type IAllergic Diseases
R Valenta, S Almo, T Ball, C Dolecek… - International archives of …, 1998 - karger.com
The interaction of immunoglobulin E and otherwise harmless antigens (allergens) leadsin
sensitized individuals through effector cell activation to the immediate induction of acascade …
sensitized individuals through effector cell activation to the immediate induction of acascade …
IL-4 production by PBMCs on stimulation with mite allergen is correlated with the level of serum IgE antibody against mite in children with bronchial asthma
M Kimura, S Tsuruta, T Yoshida - Journal of allergy and clinical immunology, 2000 - Elsevier
Background: Although IL-4, IL-13, and IFN-γ are known to affect IgE synthesis, it remains
unclear which one plays the most important role in in vivo IgE synthesis in atopic patients …
unclear which one plays the most important role in in vivo IgE synthesis in atopic patients …
Protease-mediated house dust mite allergen-induced reactive oxygen species production by neutrophils
M Fukunaga, Y Gon, S Nunomura, T Inoue… - International archives of …, 2011 - karger.com
A growing body of evidence indicates that neutrophils may play an important role in the
pathogenesis of asthma. However, the involvement of the house dust mite (HDM) in …
pathogenesis of asthma. However, the involvement of the house dust mite (HDM) in …
[HTML][HTML] Unlocking the allergenic structure of the major house dust mite allergen Der f 2 by elimination of key intramolecular interactions
T Takai, S Ichikawa, T Yokota, H Hatanaka, F Inagaki… - FEBS letters, 2000 - Elsevier
We report on the structural background of the remarkable reduction of allergenicity in
engineering of the major house dust mite allergen Der f 2. Disruption of intramolecular …
engineering of the major house dust mite allergen Der f 2. Disruption of intramolecular …
Hyposensitization to allergic reaction in rDer f 2-sensitized mice by the intranasal administration of a mutant of rDer f 2, C8/119S
M Yasue, T Yokota, M Fukada, T Takai… - Clinical & …, 1998 - academic.oup.com
C8/119S is a mutant of recombinant Der f 2 (rDer f 2), and lacks a disulphide bond
possessed by wild-type rDer f 2. In humans and mice, C8/119S has a very weak IgE-binding …
possessed by wild-type rDer f 2. In humans and mice, C8/119S has a very weak IgE-binding …
上海地区户尘螨的分离培养及Der p 2 基因的克隆与表达
范怡敏， 杨彬， 邵红霞， 庄义军， 程训佳 - 现代免疫学, 2006 - cqvip.com
克隆化培养上海地区户尘螨, 获得不同编码序列的重组Der P2 变应原进行当地人群血清特异性
IgG 分析, 探讨其应用价值. 从过敏性疾病患者床褥采集分离户尘螨, 采用封闭式培养系统进行 …
IgG 分析, 探讨其应用价值. 从过敏性疾病患者床褥采集分离户尘螨, 采用封闭式培养系统进行 …
[PDF][PDF] Expression of recombinant allergen, Der f 1, Der f 2 and Der f 4 using baculovirus-insect cell systems
Y Cui, L Yu, F Teng, N Wang, Y Zhou… - Archives of Medical …, 2018 - termedia.pl
Results The recombinant allergens were successfully expressed and purified from a
baculovirus expression system introduced into Sf9 cells, which were verified as being of the …
baculovirus expression system introduced into Sf9 cells, which were verified as being of the …
Comparison of skin prick test with serially diluted wild-type and genetically engineered recombinant Der f2
T Kusunoki, S Korematsu, M Harazaki, S Hosoi… - Annals of Allergy …, 2000 - Elsevier
BACKGROUND: C8/119S, a genetically engineered less allergenic mutant of group II
allergen (Der f2) of house dust mite, Dermatophagoides farinae, was constructed in order to …
allergen (Der f2) of house dust mite, Dermatophagoides farinae, was constructed in order to …
IgG1, IgG4 and IgE antibody reactivity to mutant forms of the major dust mite allergen Lep d 2 among atopic and nonatopic subjects naturally exposed to …
S Olsson, M van Hage-Hamsten… - International archives of …, 2001 - karger.com
Background: Lepidoglyphus destructor is a common dust mite causing IgE-mediated
sensitization. The major allergen, Lep d 2, has previously been cloned and expressed as …
sensitization. The major allergen, Lep d 2, has previously been cloned and expressed as …