Principles of fluoride toxicity and the cellular response: a review

NR Johnston, SA Strobel - Archives of toxicology, 2020 - Springer
Fluoride is ubiquitously present throughout the world. It is released from minerals, magmatic
gas, and industrial processing, and travels in the atmosphere and water. Exposure to low …

The pathogenesis of endemic fluorosis: Research progress in the last 5 years

W Wei, S Pang, D Sun - Journal of cellular and molecular …, 2019 - Wiley Online Library
Fluorine is one of the trace elements necessary for health. It has many physiological
functions, and participates in normal metabolism. However, fluorine has paradoxical effects …

Micronutrients impact the gut microbiota and blood glucose

NG Barra, FF Anhê, JF Cavallari… - Journal of …, 2021 - joe.bioscientifica.com
Micronutrients influence hormone action and host metabolism. Dietary minerals, trace
elements, and vitamins can alter blood glucose and cellular glucose metabolism, and …

Fluoride in the Central Nervous System and its potential influence on the development and invasiveness of brain tumours—A Research hypothesis

W Żwierełło, A Maruszewska… - International Journal of …, 2023 - mdpi.com
The purpose of this review is to attempt to outline the potential role of fluoride in the
pathogenesis of brain tumours, including glioblastoma (GBM). In this paper, we show for the …

Necessity to pay attention to the effects of low fluoride on human health: an overview of skeletal and non-skeletal damages in epidemiologic investigations and …

J Zhou, D Sun, W Wei - Biological Trace Element Research, 2023 - Springer
Due to the implementation of water improvement and fluoride reduction plans supported by
central and local governments in recent years, areas with high fluoride exposure are being …

Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and …

DT Waugh - International Journal of Environmental Research and …, 2019 - mdpi.com
In this study, several lines of evidence are provided to show that Na+, K+-ATPase activity
exerts vital roles in normal brain development and function and that loss of enzyme activity is …

Chronic treatment with fluoride affects the jejunum: insights from proteomics and enteric innervation analysis

AS Dionizio, CGS Melo, IT Sabino-Arias… - Scientific reports, 2018 - nature.com
Gastrointestinal symptoms are the first signs of fluoride (F) toxicity. In the present study, the
jejunum of rats chronically exposed to F was evaluated by proteomics, as well as by …

[HTML][HTML] Molecular basis of fluoride toxicities: beyond benefits and implications in human disorders

P Pal, NK Jha, D Pal, SK Jha, U Anand… - Genes & …, 2023 - Elsevier
Detrimental impacts of fluoride have become a global concern for several decades. Despite
its beneficial role which is restricted only in skeletal tissues, deleterious effects are also …

Changes in energy metabolism induced by fluoride: Insights from inside the mitochondria

TT Araujo, HABS Pereira, A Dionizio… - Chemosphere, 2019 - Elsevier
The mechanisms involved in changes in energy metabolism caused by excessive exposure
to fluoride (F) are not completely understood. The present study employed proteomic tools to …

Proposed mechanism for understanding the dose-and time-dependency of the effects of fluoride in the liver

HAB da Silva Pereira, AS Dionizio, TT Araujo… - Toxicology and applied …, 2018 - Elsevier
Fluoride (F) can induce changes in the expression of several liver proteins. It is suggested
that these changes are dose-and time-dependent. The objective of this study was to analyze …