Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - … and Targeted Therapy, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Peptide‐Functionalized Inorganic Oxide Nanomaterials for Solid Cancer Imaging and Therapy

X Duan, P Wang, L He, Z He, S Wang… - Advanced …, 2024 - Wiley Online Library
The diagnosis and treatment of solid tumors have undergone significant advancements
marked by a trend toward increased specificity and integration of imaging and therapeutic …

Xanthohumol ameliorates drug-induced hepatic ferroptosis via activating Nrf2/xCT/GPX4 signaling pathway

Y Deng, X Chu, Q Li, G Zhu, J Hu, J Sun, H Zeng… - Phytomedicine, 2024 - Elsevier
Background As a canonical iron-dependent form of regulated cell death (RCD), ferroptosis
plays a crucial role in chemical-induced liver injuries. Previous studies have demonstrated …

Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes

L Ding, S Dang, M Sun, D Zhou, Y Sun, E Li… - Free Radical Biology …, 2024 - Elsevier
Quercetin (Quer) is a natural flavonoid known for its inhibitory effects against various
cancers. However, the mechanism by which Quer inhibits gastric cancer (GC) has not yet …

Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity

H Tu, H Ren, J Jiang, C Shao, Y Shi, P Li - Advanced Science, 2024 - Wiley Online Library
Neutrophils, accounting for≈ 70% of human peripheral leukocytes, are key cells countering
bacterial and fungal infections. Neutrophil homeostasis involves a balance between cell …

Redox-regulating nanotherapeutics potentiating ferroptosis-driven cancer treatment

X Yang, X Sun, J Lei, X Shi, S Zhang, C Luo - Chemical Engineering …, 2024 - Elsevier
Ferroptosis has garnered considerable attention benefiting from its remarkable potential in
fighting malignant tumors. Its occurrence largely relies the overwhelming accumulation of …

Progress and challenges in tumor ferroptosis treatment strategies: a comprehensive review of metal complexes and nanomedicine

Y Su, B Liu, B Wang, L Chan, C Xiong, L Lu, X Zhang… - Small, 2024 - Wiley Online Library
Ferroptosis is a new form of regulated cell death featuring iron‐dependent lipid peroxides
accumulation to kill tumor cells. A growing body of evidence has shown the potential of …

[HTML][HTML] Iron toxicity, ferroptosis and microbiota in Parkinson's disease: Implications for novel targets

FV Carvalho, HE Landis, B Getachew… - Advances in …, 2024 - ncbi.nlm.nih.gov
Parkinson's Disease (PD) is a progressive neurodegenerative disease characterized by loss
of dopaminergic neurons in substantia nigra pars compacta (SNpc). Iron (Fe)-dependent …

Interplay of Ferroptosis and Cuproptosis in Cancer: Dissecting Metal-Driven Mechanisms for Therapeutic Potentials

J Wang, J Li, J Liu, KY Chan, HS Lee, KN Lin… - Cancers, 2024 - mdpi.com
Simple Summary In the complex world of cancer, iron and copper play essential roles as
trace metal ions that are crucial for cancer cell survival. Disruption in their metabolic …

Regulated cell death‐amplified sonodynamic anti‐tumor immune nanotherapeutics

L Zhou, Y Chen, D Xie, K Li, X Cui, CF Dietrich… - …, 2024 - Wiley Online Library
Nanomedicine‐assisted sonodynamic therapy (SDT) has emerged as one of the most
promising cancer therapies due to its unique advantages of high penetration, non‐radiation …