Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles

DC Luther, R Huang, T Jeon, X Zhang, YW Lee… - Advanced drug delivery …, 2020 - Elsevier
Inorganic nanoparticles provide multipurpose platforms for a broad range of delivery
applications. Intrinsic nanoscopic properties provide access to unique magnetic and optical …

Biomimetic particles as therapeutics

RA Meyer, JC Sunshine, JJ Green - Trends in biotechnology, 2015 - cell.com
In recent years, there have been major advances in the development of novel nanoparticle-
and microparticle-based therapeutics. An emerging paradigm is the incorporation of …

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers

CE Ashley, EC Carnes, GK Phillips, D Padilla… - Nature materials, 2011 - nature.com
Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to
mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug …

Facile synthesis of monodispersed mesoporous silica nanoparticles with ultralarge pores and their application in gene delivery

MH Kim, HK Na, YK Kim, SR Ryoo, HS Cho, KE Lee… - ACS …, 2011 - ACS Publications
Among various nanoparticles, the silica nanoparticle (SiNP) is an attractive candidate as a
gene delivery carrier due to advantages such as availability in porous forms for …

Delivery of small interfering RNA by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers

CE Ashley, EC Carnes, KE Epler, DP Padilla… - ACS …, 2012 - ACS Publications
The therapeutic potential of small interfering RNAs (siRNAs) is severely limited by the
availability of delivery platforms that protect siRNA from degradation, deliver it to the target …

Silica nanoparticle as a lymph node targeting platform for vaccine delivery

M An, M Li, J Xi, H Liu - ACS applied materials & interfaces, 2017 - ACS Publications
Nanoparticles have emerged as the platform of choice to improve the efficacy and safety of
subunit vaccines. A major challenge underlying the use of nanomaterials in vaccines lies in …

Nanoparticles‐mediated combination therapies for cancer treatment

B Shrestha, L Tang, G Romero - Advanced Therapeutics, 2019 - Wiley Online Library
Cancer is a dynamic disease characterized by its heterogeneous nature. This heterogeneity
results in critical problems that interfere with the eradication of cancer tumors such as …

Recent advances in the development of nanoparticles for multimodality imaging and therapy of cancer

M Liu, RC Anderson, X Lan, PS Conti… - Medicinal Research …, 2020 - Wiley Online Library
This review explores recent work directed toward the development of nanoparticles (NPs) for
multimodality cancer imaging and targeted cancer therapy. In the growing era of precision …

Experimental aspects of colloidal interactions in mixed systems of liposome and inorganic nanoparticle and their applications

R Michel*, M Gradzielski* - International journal of molecular sciences, 2012 - mdpi.com
In the past few years, growing attention has been devoted to the study of the interactions
taking place in mixed systems of phospholipid membranes (for instance in the form of …

The eradication of breast cancer cells and stem cells by 8-hydroxyquinoline-loaded hyaluronan modified mesoporous silica nanoparticle-supported lipid bilayers …

D Wang, J Huang, X Wang, Y Yu, H Zhang, Y Chen… - Biomaterials, 2013 - Elsevier
Breast cancer stem cells (BCSCs), which can fully recapitulate the tumor origin and are often
resistant to chemotherapy and radiotherapy, are currently considered as a major obstacle for …