Mammalian prions are lethal transmissible pathogens that cause fatal neurodegenerative
diseases in humans and animals. They consist of fibrils of misfolded, host-encoded prion …

Introduction Brain diseases including brain tumor, Alzheimer's disease, Parkinson's disease,
etc. are difficult to treat. The blood–brain barrier (BBB) is a major obstacle for drug delivery …

The self-association of amylogenic proteins to the fibril form is considered a pivotal factor in
the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD). PD …

Alzheimer's disease is characterized by two major neuropathological hallmarks—the
extracellular β-amyloid plaques and intracellular neurofibrillary tangles consisting of …

Amyotrophic lateral sclerosis (ALS) is a devastating motoneuron disease, in which lower
motoneurons lose control of skeletal muscles. Degeneration of neuromuscular junctions …

Many neurodegenerative diseases, including Huntington's disease (HD) and Alzheimer's
disease (AD), occur due to an accumulation of aggregation-prone proteins, which results in …

The pathophysiological mechanisms driving disease progression of frontotemporal lobar
degeneration (FTLD) and corresponding biomarkers are not fully understood. We leveraged …

The complex and heterogeneous nature of Parkinson disease (PD) is still not fully
understood, however, increasing evidence supports mitochondrial impairments as a major …

阿尔茨海默病存在2 个主要的神经病理学特征: 细胞外β 淀粉样蛋白斑块和细胞内过度磷酸化tau
蛋白聚集成的神经纤维缠结. 最近有研究发现微管相关蛋白tau 的失调, 特别是特异性蛋白水解 …

Neurodegenerative diseases are complex disorders that affect various regions and cells in
the central nervous system, sharing common hallmark features of progression. Intrinsic and …