Effects of sorafenib and quercetin alone or in combination in treating hepatocellular carcinoma: in vitro and in vivo approaches

S Abdu, N Juaid, A Amin, M Moulay, N Miled - Molecules, 2022 - mdpi.com
Sorafenib is the first drug approved to treat advanced hepatocellular carcinoma (HCC) and
continues as the gold-standard therapy against HCC. However, acquired drug resistance …

Therapeutic effects of crocin alone or in combination with sorafenib against hepatocellular carcinoma: in vivo & in vitro insights

S Abdu, N Juaid, A Amin, M Moulay, N Miled - Antioxidants, 2022 - mdpi.com
This study investigated the therapeutic effects of the phytochemical crocin alone or in
combination with sorafenib both in rats chemically induced with hepatocellular carcinoma …

Evaluation of the protective role of resveratrol against sepsis caused by LPS via TLR4/NF‐κB/TNF‐α signaling pathways: Experimental study

A Okan, Z Doğanyiğit, S Yilmaz, S Uçar… - Cell Biochemistry …, 2023 - Wiley Online Library
The development and progression of sepsis are multifactorial and influence the
immunological, endocrine, and cardiovascular systems of the body. Our knowledge of the …

Curcumin can improve ecstasy-induced hippocampal damage in rat

Z Nazari, K Bahrehbar, H Sepehri… - … and Environmental Health …, 2023 - Springer
Objective Ecstasy can damage the hippocampus, which impairs memory and learning.
Using anti-inflammatory compounds such as curcumin may improve the side effects of …

Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region‐associated protein synthesis and TLR4/NF‐κB signaling pathway

S Yilmaz, Z Doğanyiğit, AO Oflamaz… - Chemical biology & …, 2023 - Wiley Online Library
In this study, the protective effect of melatonin was investigated in lipopolysaccharide
induced sepsis model. Twenty‐eight rats were randomly divided: Control, Melatonin, LPS …

Phytanic acid-induced neurotoxicological manifestations and apoptosis ameliorated by mitochondria-mediated actions of melatonin

S Chaudhary, U Sahu, S Kar, S Parvez - Molecular Neurobiology, 2017 - Springer
Phytanic acid, a saturated branched chain fatty acid and a major constituent of human diet,
is predominantly found in dairy products, meat, and fish. It is a degradation product from the …

Neuroprotective effects of thymoquinone against MDMA-induced neurotoxicity

NS Mustafa, N Mohamad, ANH Bakar… - Research Journal of …, 2021 - indianjournals.com
MDMA (3, 4-methylenedioxymethamphetamine) is a psychoactive substance that is
associated with neurotoxicity. MDMA exposure to human results in the degeneration of …