Baicalein: A metabolite with promising antineoplastic activity

HS Tuli, V Aggarwal, J Kaur, D Aggarwal, G Parashar… - Life Sciences, 2020 - Elsevier
Cancer, being a multifactorial disease has diverse presentation in different subgroups which
is mainly attributed to heterogenous presentation of tumor cells. This cancer cell …

[HTML][HTML] Autophagy: Mechanisms and therapeutic potential of flavonoids in cancer

X Pang, X Zhang, Y Jiang, Q Su, Q Li, Z Li - Biomolecules, 2021 - mdpi.com
Autophagy, which is a conserved biological process and essential mechanism in
maintaining homeostasis and metabolic balance, enables cells to degrade cytoplasmic …

Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis

Y Wan, H Yu, W Fan - Free Radical Biology and Medicine, 2023 - Elsevier
Osteoarthritis (OA) is a common degenerative disease of articular cartilage, and there is
currently no effective treatment. Baicalein, a flavonoid extracted from plants of the Scutellaria …

[HTML][HTML] Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy

Q Meng, Y Li, T Ji, Y Chao, J Li, Y Fu, S Wang… - Journal of Advanced …, 2021 - Elsevier
Introduction Excessive inflammation and the pyroptosis of vascular endothelial cells caused
by estrogen deficiency is one cause of atherosclerosis in post-menopausal women. The …

[HTML][HTML] Baicalein as promising anticancer agent: A comprehensive analysis on molecular mechanisms and therapeutic perspectives

AKMH Morshed, S Paul, A Hossain, T Basak… - Cancers, 2023 - mdpi.com
Simple Summary Cancer is a multifactorial disease characterized by excessive cell
proliferation in a specific organ. The most common treatments include chemotherapy …

Natural compounds modulate the crosstalk between apoptosis-and autophagy-regulated signaling pathways: Controlling the uncontrolled expansion of tumor cells

C Braicu, O Zanoaga, AA Zimta, AB Tigu… - Seminars in Cancer …, 2022 - Elsevier
Due to the high number of annual cancer–related deaths, and the economic burden that this
malignancy affects today's society, the study of compounds isolated from natural sources …

[HTML][HTML] Therapeutic strategies targeting AMPK-dependent autophagy in cancer cells

W Yuan, W Fang, R Zhang, H Lyu, S Xiao… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Macroautophagy is a health-modifying process of engulfing misfolded or aggregated
proteins or damaged organelles, coating these proteins or organelles into vesicles, fusion of …

[HTML][HTML] Promising Role of the Scutellaria baicalensis Root Hydroxyflavone–Baicalein in the Prevention and Treatment of Human Diseases

M Chmiel, M Stompor-Gorący - International Journal of Molecular …, 2023 - mdpi.com
Plant roots, due to a high content of natural antioxidants for many years, have been used in
herbal medicine. It has been documented that the extract of Baikal skullcap (Scutellaria …

[HTML][HTML] Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review

E Verma, A Kumar, UD Daimary, D Parama… - Journal of Functional …, 2021 - Elsevier
Cancer is one of the deadliest diseases worldwide which kills approximately 10 million
people annually. Although, substantial improvements have been made in the treatment …

Baicalein enhanced cisplatin sensitivity of gastric cancer cells by inducing cell apoptosis and autophagy via Akt/mTOR and Nrf2/Keap 1 pathway

P Li, J Hu, B Shi, J Tie - Biochemical and Biophysical Research …, 2020 - Elsevier
Baicalein is a natural flavonoid with various pharmacological activities including antitumor.
The synergistic anti-cancer effect of the combination of baicalein and Cisplatin (DDP) on …