Multidrug transporters constitute major mechanisms of MDR in human cancers. The ABCB1
(MDR1) gene encodes a well-characterized transmembrane transporter, termed P …

Environmental lead (Pb) exposure is closely associated with pathogenesis of a range of
neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Many chemotherapy regiments are successfully used to treat breast cancer; however, often
breast cancer cells develop drug resistance that usually leads to a relapse and worsening of …

The human genome contains a number of methyl CpG binding proteins that translate DNA
methylation into a physiological response. To gain insight into the function of MBD2 and …

We investigated the role of the breast cancer resistance protein (BCRP/ABCG2) in drug
resistance in multiple myeloma (MM). Human MM cell lines, and MM patient plasma cells …

Introduction Ductal carcinoma in situ (DCIS) is a non-invasive lesion of the breast that is
frequently detected by mammography and subsequently removed by surgery. However, it is …

Rhabdoid tumor is a rare, highly aggressive malignancy that primarily affects infants and
young children. These tumors typically arise in the brain and kidney, although extrarenal …

Purpose: To investigate SGI-110 as a “chemosensitizer” in ovarian cancer and to assess its
effects on tumor suppressor genes (TSG) and chemoresponsiveness-associated genes …

Cancer cells are characterized by epigenetic dysregulation, including global genome
hypomethylation, regional hypo-and hypermethylation, altered histone modifications, and …

Background Breast cancer is the most frequent cancer in women and consists of a
heterogeneous collection of diseases with distinct histopathological, genetic and epigenetic …